Pedersen Elisabeth A, Shiozawa Yusuke, Mishra Anjali, Taichman Russell S
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA.
Front Biosci (Schol Ed). 2012 Jan 1;4(1):1-15. doi: 10.2741/s247.
Although the hematopoietic stem cell (HSC) niche has been an active area of study, the concept of the bone marrow microenvironment (BMM) harboring a niche for solid metastatic tumor cells has only recently been considered. The HSC niche and microenvironment that is thought to constitute the solid tumor niche share many of the same structural and functional components, suggesting the possibility that the HSC and tumor niche are one in the same. The osteoblast is a critical component for each of these niches, and is important for regulating cellular processes such homing and migration, growth and survival, and quiescence and dormancy. Current understanding of the HSC niche may provide more insight to better defining the solid tumor niche. As role of the niche in regulating these processes is better understood, new insights to the role of the BMM in metastatic disease may be gained, and provide more potential targets for therapy.
尽管造血干细胞（HSC）微环境一直是一个活跃的研究领域，但骨髓微环境（BMM）中存在实体转移性肿瘤细胞微环境这一概念直到最近才被考虑。被认为构成实体瘤微环境的HSC微环境和骨髓微环境共享许多相同的结构和功能成分，这表明HSC和肿瘤微环境可能是同一事物。成骨细胞是这些微环境中的关键组成部分，对于调节归巢和迁移、生长和存活以及静止和休眠等细胞过程很重要。目前对HSC微环境的理解可能为更好地定义实体瘤微环境提供更多见解。随着对微环境在调节这些过程中的作用有了更深入的了解，可能会获得关于BMM在转移性疾病中作用的新见解，并提供更多潜在的治疗靶点。
