动脉粥样硬化中巨噬细胞的功能：TRP 通道的潜在作用。
Macrophage function in atherosclerosis: potential roles of TRP channels.
机构信息
Department of Physiology and Pharmacology, University of Toledo College of Medicine, Health Science Campus, OH, USA.
出版信息
Channels (Austin). 2012 May-Jun;6(3):141-8. doi: 10.4161/chan.20292.
Abstract
Cation channels of the Transient Receptor Potential Canonical (TRPC) group, which belong to the larger TRP superfamily of channel proteins, are critical players in cardiovascular disease. Recent studies underscored a role of TRPC3 in macrophage survival and efferocytosis, two critical events in atherosclerosis lesion development. Also, other members of the TRP channel superfamily are found expressed in monocytes/macrophages, where they participate in processes that might be of significance to atherogenesis. These observations set a framework for future studies aimed at defining the ultimate functions not only of TRPC3, but probably other TRP channels, in macrophage biology. The purpose of this manuscript is to provide a timely revision of existing evidence on the role of members of the TRP channel superfamily, in particular TRPCs, in macrophages and discuss it in the context of the macrophage's function in atherogenesis.
摘要
瞬时受体电位经典（TRPC）通道家族的阳离子通道属于更大的 TRP 通道蛋白超家族，是心血管疾病的关键参与者。最近的研究强调了 TRPC3 在巨噬细胞存活和胞吐作用中的作用，这是动脉粥样硬化病变发展的两个关键事件。此外，TRP 通道超家族的其他成员也在单核细胞/巨噬细胞中表达，它们参与的过程可能对动脉粥样形成具有重要意义。这些观察结果为未来的研究奠定了基础，旨在确定 TRPC3 甚至其他 TRP 通道在巨噬细胞生物学中的最终功能。本文的目的是及时修订 TRP 通道超家族成员（特别是 TRPCs）在巨噬细胞中的作用的现有证据，并结合巨噬细胞在动脉粥样形成中的功能对此进行讨论。
相似文献
1
Macrophage function in atherosclerosis: potential roles of TRP channels.动脉粥样硬化中巨噬细胞的功能：TRP 通道的潜在作用。
Channels (Austin). 2012 May-Jun;6(3):141-8. doi: 10.4161/chan.20292.
2
On the Roles of the Transient Receptor Potential Canonical 3 (TRPC3) Channel in Endothelium and Macrophages: Implications in Atherosclerosis.瞬时受体电位香草酸亚型3（TRPC3）通道在内皮细胞和巨噬细胞中的作用：对动脉粥样硬化的影响
Adv Exp Med Biol. 2016;898:185-99. doi: 10.1007/978-3-319-26974-0_9.
3
"Immuno-Transient Receptor Potential Ion Channels": The Role in Monocyte- and Macrophage-Mediated Inflammatory Responses.“免疫瞬变受体电位离子通道”：在单核细胞和巨噬细胞介导的炎症反应中的作用。
Front Immunol. 2018 Jun 6;9:1273. doi: 10.3389/fimmu.2018.01273. eCollection 2018.
4
Bone marrow deficiency of TRPC3 channel reduces early lesion burden and necrotic core of advanced plaques in a mouse model of atherosclerosis.骨髓 TRPC3 通道缺陷可减少动脉粥样硬化小鼠模型早期病变负担和晚期斑块的坏死核心。
Cardiovasc Res. 2014 Jan 1;101(1):138-44. doi: 10.1093/cvr/cvt231. Epub 2013 Oct 6.
5
TRPC channels as prospective targets in atherosclerosis: terra incognita.瞬时受体电位通道作为动脉粥样硬化的潜在靶点：未知领域。
Front Biosci (Schol Ed). 2012 Jan 1;4(1):157-66. doi: 10.2741/258.
6
TRP channels.瞬时受体电位通道
Annu Rev Biochem. 2007;76:387-417. doi: 10.1146/annurev.biochem.75.103004.142819.
7
On the role of endothelial TRPC3 channels in endothelial dysfunction and cardiovascular disease.内皮瞬时受体电位通道3（TRPC3）在内皮功能障碍和心血管疾病中的作用
Cardiovasc Hematol Agents Med Chem. 2012 Sep;10(3):265-74. doi: 10.2174/187152512802651051.
8
Transient receptor potential channels in endothelium: solving the calcium entry puzzle?内皮细胞中的瞬时受体电位通道：解开钙内流之谜？
Endothelium. 2003;10(1):5-15. doi: 10.1080/10623320303356.
9
Structure-functional intimacies of transient receptor potential channels.瞬时受体电位通道的结构-功能关系。
Q Rev Biophys. 2009 Aug;42(3):201-46. doi: 10.1017/S0033583509990072.
10
TRPC channels: Structure, function, regulation and recent advances in small molecular probes.TRPC 通道：结构、功能、调控及小分子探针的最新进展。
Pharmacol Ther. 2020 May;209:107497. doi: 10.1016/j.pharmthera.2020.107497. Epub 2020 Jan 28.
引用本文的文献
1
Six Decades of History of Hypertension Research at the University of Toledo: Highlighting Pioneering Contributions in Biochemistry, Genetics, and Host-Microbiota Interactions.六十年托莱多大学高血压研究史：重点介绍生物化学、遗传学和宿主-微生物相互作用方面的开创性贡献。
Curr Hypertens Rep. 2022 Dec;24(12):669-685. doi: 10.1007/s11906-022-01226-0. Epub 2022 Oct 27.
2
The role of calmodulin and calmodulin-dependent protein kinases in the pathogenesis of atherosclerosis.钙调蛋白及钙调蛋白依赖性蛋白激酶在动脉粥样硬化发病机制中的作用。
Tzu Chi Med J. 2021 Oct 5;34(2):160-168. doi: 10.4103/tcmj.tcmj_119_21. eCollection 2022 Apr-Jun.
3
The histone methyltransferase Ezh2 restrains macrophage inflammatory responses.组蛋白甲基转移酶 Ezh2 抑制巨噬细胞炎症反应。
FASEB J. 2021 Oct;35(10):e21843. doi: 10.1096/fj.202100044RRR.
4
TRPC and TRPV Channels' Role in Vascular Remodeling and Disease.TRPC 和 TRPV 通道在血管重塑和疾病中的作用。
Int J Mol Sci. 2020 Aug 25;21(17):6125. doi: 10.3390/ijms21176125.
5
Ca Flux: Searching for a Role in Efferocytosis of Apoptotic Cells in Atherosclerosis.钙通量：探寻其在动脉粥样硬化中凋亡细胞胞葬作用中的角色
J Clin Med. 2019 Nov 21;8(12):2047. doi: 10.3390/jcm8122047.
6
Canonical Transient Receptor Potential Channels and Their Link with Cardio/Cerebro-Vascular Diseases.典型瞬时受体电位通道及其与心脑血管疾病的联系。
Biomol Ther (Seoul). 2017 Sep 1;25(5):471-481. doi: 10.4062/biomolther.2016.096.
7
Reduced Necrosis and Content of Apoptotic M1 Macrophages in Advanced Atherosclerotic Plaques of Mice With Macrophage-Specific Loss of Trpc3.巨噬细胞特异性 Trpc3 缺失小鼠晚期动脉粥样硬化斑块中坏死减少和凋亡 M1 巨噬细胞含量降低。
Sci Rep. 2017 Feb 10;7:42526. doi: 10.1038/srep42526.
8
Mouse models of atherosclerosis: a historical perspective and recent advances.动脉粥样硬化的小鼠模型：历史回顾与最新进展
Lipids Health Dis. 2017 Jan 17;16(1):12. doi: 10.1186/s12944-016-0402-5.
9
Reduced size and macrophage content of advanced atherosclerotic lesions in mice with bone marrow specific deficiency of alpha 7 nicotinic acetylcholine receptor.α7烟碱型乙酰胆碱受体骨髓特异性缺乏的小鼠中晚期动脉粥样硬化病变的尺寸和巨噬细胞含量减小。
PLoS One. 2015 Mar 31;10(3):e0124584. doi: 10.1371/journal.pone.0124584. eCollection 2015.
10
Reduced endoplasmic reticulum stress-induced apoptosis and impaired unfolded protein response in TRPC3-deficient M1 macrophages.TRPC3 缺陷型 M1 巨噬细胞内质网应激诱导的细胞凋亡减少和未折叠蛋白反应受损。
Am J Physiol Cell Physiol. 2014 Sep 15;307(6):C521-31. doi: 10.1152/ajpcell.00369.2013. Epub 2014 Jul 16.
本文引用的文献
1
Increased migration of monocytes in essential hypertension is associated with increased transient receptor potential channel canonical type 3 channels.原发性高血压中单核细胞的迁移增加与瞬时受体电位通道经典型 3 通道的增加有关。
PLoS One. 2012;7(3):e32628. doi: 10.1371/journal.pone.0032628. Epub 2012 Mar 16.
2
Multiple roles for neutrophils in atherosclerosis.中性粒细胞在动脉粥样硬化中的多重作用。
Circ Res. 2012 Mar 16;110(6):875-88. doi: 10.1161/CIRCRESAHA.111.257535.
3
Endoplasmic reticulum stress controls M2 macrophage differentiation and foam cell formation.内质网应激控制 M2 巨噬细胞分化和泡沫细胞形成。
J Biol Chem. 2012 Apr 6;287(15):11629-41. doi: 10.1074/jbc.M111.338673. Epub 2012 Feb 22.
4
Translocation of calcium-permeable TRPV2 channel to the podosome: Its role in the regulation of podosome assembly.钙通透型 TRPV2 通道易位至足突：其在调节足突装配中的作用。
Cell Calcium. 2012 Feb;51(2):186-93. doi: 10.1016/j.ceca.2011.12.012. Epub 2012 Jan 4.
5
TRPC channels as prospective targets in atherosclerosis: terra incognita.瞬时受体电位通道作为动脉粥样硬化的潜在靶点：未知领域。
Front Biosci (Schol Ed). 2012 Jan 1;4(1):157-66. doi: 10.2741/258.
6
The role of macrophages and dendritic cells in the clearance of apoptotic cells in advanced atherosclerosis.巨噬细胞和树突状细胞在晚期动脉粥样硬化中清除凋亡细胞中的作用。
Eur J Immunol. 2011 Sep;41(9):2515-8. doi: 10.1002/eji.201141719.
7
Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes.瞬时受体电位 M 型 2 型（TRPM2）离子通道是先天免疫李斯特菌的必要条件。
Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11578-83. doi: 10.1073/pnas.1010678108. Epub 2011 Jun 27.
8
Erythropoietin increases expression and function of transient receptor potential canonical 5 channels.促红细胞生成素增加瞬时受体电位经典通道 5 型的表达和功能。
Hypertension. 2011 Aug;58(2):317-24. doi: 10.1161/HYPERTENSIONAHA.111.173690. Epub 2011 Jun 20.
9
Impairment of survival signaling and efferocytosis in TRPC3-deficient macrophages.TRPC3 缺陷型巨噬细胞中存活信号和吞噬作用受损。
Biochem Biophys Res Commun. 2011 Jul 8;410(3):643-7. doi: 10.1016/j.bbrc.2011.06.045. Epub 2011 Jun 13.
10
Monocyte and macrophage dynamics during atherogenesis.动脉粥样硬化形成过程中的单核细胞和巨噬细胞动力学。
Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1506-16. doi: 10.1161/ATVBAHA.110.221127.
Zotero 插件