Department of Physiology and Pharmacology, University of Toledo College of Medicine, Health Science Campus, OH, USA.
Channels (Austin). 2012 May-Jun;6(3):141-8. doi: 10.4161/chan.20292.
Cation channels of the Transient Receptor Potential Canonical (TRPC) group, which belong to the larger TRP superfamily of channel proteins, are critical players in cardiovascular disease. Recent studies underscored a role of TRPC3 in macrophage survival and efferocytosis, two critical events in atherosclerosis lesion development. Also, other members of the TRP channel superfamily are found expressed in monocytes/macrophages, where they participate in processes that might be of significance to atherogenesis. These observations set a framework for future studies aimed at defining the ultimate functions not only of TRPC3, but probably other TRP channels, in macrophage biology. The purpose of this manuscript is to provide a timely revision of existing evidence on the role of members of the TRP channel superfamily, in particular TRPCs, in macrophages and discuss it in the context of the macrophage's function in atherogenesis.
瞬时受体电位经典（TRPC）通道家族的阳离子通道属于更大的 TRP 通道蛋白超家族，是心血管疾病的关键参与者。最近的研究强调了 TRPC3 在巨噬细胞存活和胞吐作用中的作用，这是动脉粥样硬化病变发展的两个关键事件。此外，TRP 通道超家族的其他成员也在单核细胞/巨噬细胞中表达，它们参与的过程可能对动脉粥样形成具有重要意义。这些观察结果为未来的研究奠定了基础，旨在确定 TRPC3 甚至其他 TRP 通道在巨噬细胞生物学中的最终功能。本文的目的是及时修订 TRP 通道超家族成员（特别是 TRPCs）在巨噬细胞中的作用的现有证据，并结合巨噬细胞在动脉粥样形成中的功能对此进行讨论。
