在单独或联合使用卡泊芬净或尼克霉素 Z 的影响下，烟曲霉细胞壁成分几丁质和β-葡聚糖的重排。
Reshuffling of Aspergillus fumigatus cell wall components chitin and β-glucan under the influence of caspofungin or nikkomycin Z alone or in combination.
机构信息
Department of Medical Microbiology & Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
出版信息
Antimicrob Agents Chemother. 2012 Mar;56(3):1595-8. doi: 10.1128/AAC.05323-11. Epub 2011 Dec 27.
Abstract
Chitin and β-glucan are major cell wall components of Aspergillus spp. We investigated the antifungal activity of chitin synthesis inhibitors nikkomycin Z, polyoxin D, flufenoxuron, lufenuron, and teflubenzuron, alone and combined with the β-glucan synthesis inhibitor caspofungin. Only nikkomycin Z and caspofungin were found to act synergistically. The nikkomycin Z-induced chitin decrease corresponded with a β-glucan increase, while with the caspofungin-induced β-glucan decrease, an increase in chitin was found. This could explain the synergistic activity of this combination of drugs.
摘要
几丁质和β-葡聚糖是曲霉菌属的主要细胞壁成分。我们研究了几丁质合成抑制剂 nikkomycin Z、多氧霉素 D、氟虫脲、lufenuron 和 teflubenzuron 单独以及与β-葡聚糖合成抑制剂卡泊芬净联合使用的抗真菌活性。只有 nikkomycin Z 和卡泊芬净被发现具有协同作用。nikkomycin Z 诱导的几丁质减少伴随着β-葡聚糖的增加，而卡泊芬净诱导的β-葡聚糖减少则伴随着几丁质的增加。这可以解释这种药物组合的协同作用。
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2
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Fungal Genet Biol. 2010 Feb;47(2):117-26. doi: 10.1016/j.fgb.2009.09.003. Epub 2009 Sep 19.
3
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4
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5
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6
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