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在单独或联合使用卡泊芬净或尼克霉素 Z 的影响下，烟曲霉细胞壁成分几丁质和β-葡聚糖的重排。

Reshuffling of Aspergillus fumigatus cell wall components chitin and β-glucan under the influence of caspofungin or nikkomycin Z alone or in combination.

机构信息

Department of Medical Microbiology & Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.

出版信息

Antimicrob Agents Chemother. 2012 Mar;56(3):1595-8. doi: 10.1128/AAC.05323-11. Epub 2011 Dec 27.

DOI:10.1128/AAC.05323-11
PMID:22203603
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3294952/
Abstract

Chitin and β-glucan are major cell wall components of Aspergillus spp. We investigated the antifungal activity of chitin synthesis inhibitors nikkomycin Z, polyoxin D, flufenoxuron, lufenuron, and teflubenzuron, alone and combined with the β-glucan synthesis inhibitor caspofungin. Only nikkomycin Z and caspofungin were found to act synergistically. The nikkomycin Z-induced chitin decrease corresponded with a β-glucan increase, while with the caspofungin-induced β-glucan decrease, an increase in chitin was found. This could explain the synergistic activity of this combination of drugs.

摘要

几丁质和β-葡聚糖是曲霉菌属的主要细胞壁成分。我们研究了几丁质合成抑制剂 nikkomycin Z、多氧霉素 D、氟虫脲、lufenuron 和 teflubenzuron 单独以及与β-葡聚糖合成抑制剂卡泊芬净联合使用的抗真菌活性。只有 nikkomycin Z 和卡泊芬净被发现具有协同作用。nikkomycin Z 诱导的几丁质减少伴随着β-葡聚糖的增加，而卡泊芬净诱导的β-葡聚糖减少则伴随着几丁质的增加。这可以解释这种药物组合的协同作用。

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Antimicrob Agents Chemother. 2010 Jun;54(6):2738-40. doi: 10.1128/AAC.01546-09. Epub 2010 Mar 29.
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Fungal echinocandin resistance.真菌棘白菌素耐药性。
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Differential effects of inhibiting chitin and 1,3-{beta}-D-glucan synthesis in ras and calcineurin mutants of Aspergillus fumigatus.抑制烟曲霉ras和钙调神经磷酸酶突变体中几丁质和1,3-β-D-葡聚糖合成的差异效应
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Escape of Candida from caspofungin inhibition at concentrations above the MIC (paradoxical effect) accomplished by increased cell wall chitin; evidence for beta-1,6-glucan synthesis inhibition by caspofungin.在高于最低抑菌浓度（矛盾效应）的浓度下，念珠菌通过增加细胞壁几丁质而逃避卡泊芬净的抑制作用；卡泊芬净抑制β-1,6-葡聚糖合成的证据。
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Comparison of susceptibility of fungal isolates to lufenuron and nikkomycin Z alone or in combination with itraconazole.真菌分离株对虱螨脲和多氧霉素Z单独或与伊曲康唑联合使用的敏感性比较。
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Testing of the in vitro susceptibilities of Madurella mycetomatis to six antifungal agents by using the Sensititre system in comparison with a viability-based 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5- [(phenylamino)carbonyl]-2H-tetrazolium hydroxide (XTT) assay and a modified NCCLS method.采用Sensititre系统，与基于活力的2,3-双(2-甲氧基-4-硝基-5-磺基苯基)-5-[(苯基氨基)羰基]-2H-氢氧化四唑(XTT)检测法及改良的美国国立临床实验室标准化委员会(NCCLS)方法相比较，对马杜拉足分支菌的体外药敏性进行检测。
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