Steinbach William J, Cramer Robert A, Perfect B Zachary, Henn Christina, Nielsen Kirsten, Heitman Joseph, Perfect John R
Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA.
Antimicrob Agents Chemother. 2007 Aug;51(8):2979-81. doi: 10.1128/AAC.01394-06. Epub 2007 May 14.
Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillus fumigatus. Quantification of 1,3-beta-d-glucan revealed decreased amounts in the calcineurin A (DeltacnaA) mutant. Calcineurin can be an excellent adjunct therapeutic target in combination with other cell wall inhibitors against A. fumigatus.
钙调神经磷酸酶突变或抑制增强了细胞壁抑制剂卡泊芬净或多氧霉素Z对烟曲霉的抗真菌形态学效应。对1,3-β-D-葡聚糖的定量分析显示,钙调神经磷酸酶A(DeltacnaA)突变体中的含量降低。钙调神经磷酸酶与其他抗烟曲霉细胞壁抑制剂联合使用时,可能是一个很好的辅助治疗靶点。