Werka T, Marek P
Department of Neurophysiology, Nencki Insititute of Experimental Biology, Warsaw, Poland.
Acta Neurobiol Exp (Wars). 1990;50(1-2):13-22.
In two experiments the role of the central nucleus of the amygdala under two modes of foot-shock analgesia was studied in 39 male Möll-Wistar rats. In Experiment I a 4 min continuous foot-shock, dependent on neural mechanism was used as a stressor. Analgesia was produced by regularly intermitted 20 min of foot-shock action in Experiment II which evoke an opioid, humorally mediated mechanism. The results suggested that the central nucleus is involved only in the humoral regulation of the opioid form of analgesia. This finding fits well with the concept of limbic control of the anterior pituitary and the pituitary-adrenocortical axis, and points to the role of the amygdaloid complex in processing of stressful stimuli.
在两项实验中，对39只雄性莫尔-威斯塔大鼠研究了杏仁核中央核在两种足部电击镇痛模式下的作用。在实验I中，将一种依赖神经机制的4分钟连续足部电击用作应激源。在实验II中，通过定期间歇20分钟的足部电击作用产生镇痛，这种作用引发了一种阿片样物质介导的体液机制。结果表明，中央核仅参与阿片类镇痛形式的体液调节。这一发现与边缘系统对垂体前叶和垂体-肾上腺皮质轴的控制概念相契合，并指出了杏仁复合体在应激刺激处理中的作用。
