Institute for Stem Cell Research, MRC Centre for Regenerative Medicine, 5 Little France Drive, Edinburgh EH16 4UU, Scotland, UK.
BMC Biol. 2011 Dec 28;9:88. doi: 10.1186/1741-7007-9-88.
The close association between hematopoietic and endothelial cells during embryonic development led to the proposal that they may originate from a common ancestor--the hemangioblast. Due to a lack of unique specific markers for in vivo cell fate tracking studies, evidence supporting this theory derives mainly from in vitro differentiation studies. Teixeira and colleagues describe a novel enhancer that drives specific eGFP expression in blood islands of the electroporated chick embryo, thereby presenting a tool potentially suitable for analysis of hemangioblast differentiation and development of blood islands.
在胚胎发育过程中，造血细胞和内皮细胞密切相关，这导致人们提出它们可能起源于一个共同的祖先——血岛细胞。由于缺乏用于体内细胞命运追踪研究的独特特异性标记物，支持这一理论的证据主要来自体外分化研究。Teixeira 及其同事描述了一个新的增强子，该增强子可在电穿孔鸡胚的血岛中驱动特异性 eGFP 表达，从而提供了一种潜在适用于分析血岛细胞分化和发育的工具。
