MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, University of Edinburgh, Edinburgh EH9 3JQ, UK.
Development. 2011 Mar;138(6):1017-31. doi: 10.1242/dev.040998.
Definitive hematopoietic stem cells (HSCs) lie at the foundation of the adult hematopoietic system and provide an organism throughout its life with all blood cell types. Several tissues demonstrate hematopoietic activity at early stages of embryonic development, but which tissue is the primary source of these important cells and what are the early embryonic ancestors of definitive HSCs? Here, we review recent advances in the field of HSC research that have shed light on such questions, while setting them into a historical context, and discuss key issues currently circulating in this field.
明确的造血干细胞（HSCs）位于成人造血系统的基础，并为生物体提供其一生中所有的血细胞类型。在胚胎发育的早期，有几个组织表现出造血活性，但哪种组织是这些重要细胞的主要来源，以及明确的 HSCs 的早期胚胎祖先是什么？在这里，我们回顾了造血干细胞研究领域的最新进展，这些进展阐明了这些问题，同时将其置于历史背景下，并讨论了该领域目前存在的关键问题。
