新型血管舒张吲哚生物碱，塔贝尼亚辛 A 和 B，来自变叶狗牙花。
New vasorelaxant indole alkaloids, taberniacins A and B, from Tabernaemontana divaricata.
机构信息
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan.
出版信息
J Nat Med. 2019 Jun;73(3):627-632. doi: 10.1007/s11418-019-01293-9. Epub 2019 Mar 7.
PMID:30847757
Abstract
Taberniacins A (1) and B (2), new indole alkaloids, were isolated from the stems of Tabernaemontana divaricata (Apocynaceae). Structure elucidation of 1 and 2 was based on spectroscopic methods and total synthesis. Each alkaloid showed vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.
摘要
Taberniacins A (1) 和 B (2)，两种新的吲哚生物碱，从 Tabernaemontana divaricata（夹竹桃科）的茎中分离得到。1 和 2 的结构阐明基于光谱方法和全合成。每种生物碱均显示出对离体大鼠主动脉中苯肾上腺素诱导的收缩的血管舒张活性。
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