Laboratory of Environmental Analytical Chemistry (05/UR/12-03), University of Carthage, Faculty of Sciences, Bizerte, 7021 Zarzouna, Tunisia.
Mar Pollut Bull. 2012 Feb;64(2):241-51. doi: 10.1016/j.marpolbul.2011.11.026. Epub 2011 Dec 27.
The aim of the study was to evaluate the impact of environmental contaminants on oxidative stress, genotoxic and histopathologic biomarkers in liver of mullet (Mugil cephalus) and sea bass (Dicentrarchus labrax) collected from a polluted coastal lagoon (Bizerte Lagoon) in comparison to a reference site (the Mediterranean Sea). Antioxidant enzyme activities were lower in fish from the polluted site compared with fish from the reference site, suggesting deficiency of the antioxidant system to compensate for oxidative stress. DNA damage was higher in both fish species from the contaminated site indicating genotoxic effects. The liver histopathological analysis revealed alterations in fish from Bizerte Lagoon. Hepatocytes from both fish species featured extensive lipid-type vacuolation and membrane disruption. Results suggest that the selected biomarkers in both fish species are useful for the assessment of pollution impacts in coastal environments influenced by multiple pollution sources.
本研究旨在评估环境污染物对来自污染沿海泻湖（比塞大泻湖）和参照点（地中海）的梭鱼（Mugil cephalus）和海鲈（Dicentrarchus labrax）肝脏中氧化应激、遗传毒性和组织病理学生物标志物的影响。与参照点相比，污染点的鱼类抗氧化酶活性较低，表明抗氧化系统不足，无法补偿氧化应激。两种鱼类的 DNA 损伤均在污染点较高，表明存在遗传毒性。比塞大泻湖的鱼类肝脏组织病理学分析显示出改变。两种鱼类的肝细胞均表现出广泛的脂类空泡和膜破裂。结果表明，两种鱼类的选定生物标志物可用于评估受多种污染源影响的沿海环境的污染影响。
