Liu M Y, Lin H H, Chen P C
Department of Gastroenterology, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China.
Am J Gastroenterol. 1990 Oct;85(10):1343-5.
To clarify the clinical significance of dyspepsia in patients with bleeding duodenal ulcer, we studied 298 patients prospectively. Ages of patients ranged from 16 to 81 yr (mean 45.9). There were 244 (82%) dyspeptic and 54 (18%) nondyspeptic patients. In the dyspeptic group, significantly more patients were taking nonsteroidal anti-inflammatory drugs. In the nondyspeptic group, there was a higher percentage of patients with duodenal bulb deformity (p less than 0.005), which deformity was related to previous peptic ulcer disease. The age, sex, past history of dyspepsia or bleeding, consumption of alcohol and cigarettes, and the hospital course of the two groups of patients did not differ significantly. Our results show that the clinical course of duodenal ulcer hemorrhage is not significantly different in patients with or without dyspepsia, and indicate that bleeding and dyspepsia probably are two independent presentations in the natural course of the disease. The significance of the correlation between dyspepsia and duodenal bulb deformity is discussed.
为阐明消化不良在十二指肠溃疡出血患者中的临床意义，我们对298例患者进行了前瞻性研究。患者年龄在16至81岁之间（平均45.9岁）。其中有244例（82%）消化不良患者和54例（18%）无消化不良患者。在消化不良组中，服用非甾体抗炎药的患者明显更多。在无消化不良组中，十二指肠球部畸形患者的比例更高（p<0.005），这种畸形与既往消化性溃疡病有关。两组患者的年龄、性别、既往消化不良或出血史、烟酒消耗量以及住院病程差异均无统计学意义。我们的结果表明，有或无消化不良的十二指肠溃疡出血患者的临床病程差异无统计学意义，提示出血和消化不良可能是该疾病自然病程中的两种独立表现。文中讨论了消化不良与十二指肠球部畸形之间相关性的意义。
