Materials Science and Chemical Engineering Department, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.
J Biomater Appl. 2013 Mar;27(7):872-90. doi: 10.1177/0885328211429193. Epub 2011 Dec 29.
Fabrication of 3-D highly porous, bioactive, and mechanically competent scaffolds represents a significant challenge of bone tissue engineering. In this work, Bioglass®-derived glass-ceramic scaffolds actually fulfilling this complex set of requirements were successfully produced through the sponge replication method. Scaffold processing parameters and sintering treatment were carefully designed in order to obtain final porous bodies with pore content (porosity above 70 %vol), trabecular architecture and mechanical properties (compressive strength up to 3 MPa) analogous to those of the cancellous bone. Influence of the Bioglass® particles size on the structural and mechanical features of the sintered scaffolds was considered and discussed. Relationship between porosity and mechanical strength was investigated and modeled. Three-dimensional architecture, porosity, mechanical strength and in vitro bioactivity of the optimized Bioglass®-derived scaffolds were also compared to those of CEL2-based glass-ceramic scaffolds (CEL2 is an experimental bioactive glass originally developed by the authors at Politecnico di Torino) fabricated by the same processing technique, in an attempt at understanding the role of different bioactive glass composition on the major features of scaffolds prepared by the same method.
制备具有三维高度多孔、生物活性和机械性能的支架是骨组织工程的一个重大挑战。在这项工作中，通过海绵复制法成功制备了满足这一组复杂要求的 Bioglass®衍生的玻璃陶瓷支架。仔细设计了支架加工参数和烧结处理，以获得具有类似于松质骨的孔含量（孔隙率高于 70%）、小梁结构和机械性能（抗压强度高达 3 MPa）的最终多孔体。研究并讨论了 Bioglass®颗粒尺寸对烧结支架结构和机械性能的影响。研究并建立了孔隙率与机械强度之间的关系。还比较了优化的 Bioglass®衍生支架的三维结构、孔隙率、机械强度和体外生物活性与基于 CEL2 的玻璃陶瓷支架（CEL2 是都灵理工大学的作者最初开发的实验性生物活性玻璃）的这些性能，试图了解不同生物活性玻璃组成对相同方法制备的支架主要特征的作用。
