共济失调毛细血管扩张症基因座在染色体11q23区域的进一步定位。
Further mapping of an ataxia-telangiectasia locus to the chromosome 11q23 region.
作者信息
Sanal O, Wei S, Foroud T, Malhotra U, Concannon P, Charmley P, Salser W, Lange K, Gatti R A
机构信息
Department of Pathology, University of California, Los Angeles 90024.
出版信息
Am J Hum Genet. 1990 Nov;47(5):860-6.
We recently mapped the gene for ataxia-telangiectasia group A (ATA) to chromosome 11q22-23 by linkage analysis, using the genetic markers THY1 and pYNB3.12 (D11S144). The most likely order was cent-AT-S144-THY1. The present paper describes further mapping of the AT locus by means of a panel of 10 markers that span approximately 60 cM in the 11q22-23 region centered around S144 and THY1. Location scores indicate that three contiguous subsegments within the [S144-THY1] segment, as well as three contiguous segments telomeric to THY1, are each unlikely to contain the AT locus, while the more centromeric [STMY-S144] segment is most likely to contain the AT locus. These data, together with recent refinements in the linkage and physical maps of 11q22-23, place the AT locus at 11q23.
我们最近通过连锁分析，利用遗传标记THY1和pYNB3.12（D11S144），将共济失调毛细血管扩张症A组（ATA）基因定位于染色体11q22 - 23。最可能的顺序是着丝粒 - AT - S144 - THY1。本文描述了通过一组10个标记对AT基因座进行进一步定位，这些标记在以S144和THY1为中心的11q22 - 23区域跨度约60厘摩。定位分数表明，[S144 - THY1]片段内的三个相邻子片段以及THY1端粒方向的三个相邻片段，各自不太可能包含AT基因座，而更靠近着丝粒的[STMY - S144]片段最有可能包含AT基因座。这些数据，连同最近对11q22 - 23连锁图谱和物理图谱的细化，将AT基因座定位在11q23。
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