通过傅克烷基化反应直接、区域选择性和选择性地制备新型硼代色氨酸。
Direct, regioselective, and chemoselective preparation of novel boronated tryptophans by Friedel-Crafts alkylation.
机构信息
Department of Biomolecular Sciences, University of Urbino, Piazza Rinascimento 6, 61029 Urbino (PU), Italy.
出版信息
Org Lett. 2012 Jan 20;14(2):600-3. doi: 10.1021/ol203216h. Epub 2011 Dec 30.
PMID:22208950
Abstract
A facile synthetic approach to the direct preparation of various novel unnatural boronated protected tryptophans using a regio- and chemoselective electrophilic substitution of 4- and 5-boronated indoles with N-protected dehydroalanine is described. The gram-scale synthesis of two free tryptophan boronic acids is also reported.
摘要
一种简便的合成方法，可通过 N-保护的脱氢丙氨酸对 4-和 5-硼吲哚进行区域和化学选择性的亲电取代，直接制备各种新型非天然硼代保护色氨酸。还报道了两种游离色氨酸硼酸的克级合成。
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