Caen University Hospital, Department of Endocrinology, Caen F-14000, France.
Diabetes Res Clin Pract. 2012 Jun;96(3):294-305. doi: 10.1016/j.diabres.2011.12.010. Epub 2011 Dec 28.
Despite recent advances in diabetes therapy including the new long- and rapid-insulin analogs, insulin intensification strategies such as basal/bolus or pump therapy and sophisticated methods for insulin titration derived from the principles of functional insulin therapy, many patients fail to reach or maintain target glycosylated hemoglobin (HbA1c) values, putting them at increased risk for vascular complications. Continuous glucose monitoring (CGM) systems represent an important advance in diabetes technology that can facilitate optimal glucose control in type 1 diabetes.
This review focuses on the efficacy and safety of CGM systems in diabetes management. The different CGM devices available are also described, as the way to use them and the educational approach to the patient in a step-by-step progression toward optimal glycemic control.
In type 1 diabetes, CGM systems are associated with 0.5-1% reduction in HbA1c without increased risk of hypoglycemia. CGM efficacy correlates with compliance to sensor wear, whatever the patient's age range.
Efficacy of CGM systems is now proven but indications, terms of use and educational issues of this new technology still need to be specified.
尽管糖尿病治疗领域最近取得了一些进展,包括新型长效和速效胰岛素类似物,但胰岛素强化策略,如基础/餐时或泵治疗,以及基于功能性胰岛素治疗原则的胰岛素滴定的复杂方法,仍有许多患者无法达到或维持糖化血红蛋白(HbA1c)目标值,使他们面临更高的血管并发症风险。连续血糖监测(CGM)系统是糖尿病技术的重要进步,可以促进 1 型糖尿病的血糖控制优化。
本综述重点介绍 CGM 系统在糖尿病管理中的疗效和安全性。还描述了不同的 CGM 设备,以及使用这些设备的方法,以及在逐步达到最佳血糖控制的过程中对患者的教育方法。
在 1 型糖尿病中,CGM 系统可使 HbA1c 降低 0.5-1%,而不会增加低血糖风险。CGM 的疗效与传感器佩戴的依从性相关,无论患者的年龄范围如何。
CGM 系统的疗效现已得到证实,但这项新技术的适应证、使用条件和教育问题仍需要进一步明确。