Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S. Second St., Suite 300, Minneapolis, MN 55454, USA.
Maturitas. 2012 Mar;71(3):267-73. doi: 10.1016/j.maturitas.2011.12.005. Epub 2011 Dec 29.
Vitamin D deficiency and mood disorders are both prevalent among the elderly. We evaluated the association between vitamin D intake and mental health-related quality of life (QOL) among elderly women participating in a large population-based study.
This study was a cross-sectional analysis of the Iowa Women's Health Study, a prospective study of cancer risk factors among post-menopausal women in Iowa that began in 1986. Additional survey data was collected from the cohort members in 1987, 1989, 1992, 1997, and 2004. Data for this analysis came from the 2004 questionnaire.
Mental health-related QOL was assessed using five scales from the Medical Outcomes Study 36-item Short-form Health Survey. QOL scores were analyzed as continuous variables using linear regression, controlling for age, energy intake, BMI, education, smoking, living arrangement, antidepressant usage, comorbidity history, and physical activity.
Low vitamin D intake (<400 IU/day) was associated with poorer QOL scores compared to women with higher intake (≥400 IU/day). Differences in QOL scores by vitamin D intake group were attenuated with multivariable adjustment, but a significant overall association between vitamin D and QOL scores persisted. Further adjustment for physical activity attenuated all differences as well as the overall association between vitamin D and QOL scores.
Women who consumed <400 IU/day of vitamin D had significantly lower mental health-related QOL compared to those who consumed ≥400 IU/day. Meeting dietary vitamin D recommendations is a potential method for improving QOL among the elderly.
维生素 D 缺乏和情绪障碍在老年人中都很常见。我们评估了维生素 D 摄入量与参与大型基于人群研究的老年女性心理健康相关生活质量（QOL）之间的关系。
本研究是对爱荷华州妇女健康研究的横断面分析，这是一项针对爱荷华州绝经后妇女癌症风险因素的前瞻性研究，始于 1986 年。1987 年、1989 年、1992 年、1997 年和 2004 年向队列成员收集了额外的调查数据。本分析的数据来自 2004 年的问卷。
使用来自医疗结果研究 36 项简短健康调查问卷的五个量表评估心理健康相关 QOL。使用线性回归分析 QOL 评分作为连续变量，控制年龄、能量摄入、BMI、教育、吸烟、居住安排、抗抑郁药使用、合并症病史和体力活动。
与高摄入量（≥400IU/天）的女性相比，低维生素 D 摄入量（<400IU/天）与较差的 QOL 评分相关。维生素 D 摄入量组之间的 QOL 评分差异在多变量调整后减弱，但维生素 D 与 QOL 评分之间仍存在显著的总体相关性。进一步调整体力活动减弱了所有差异以及维生素 D 与 QOL 评分之间的总体相关性。
每天摄入<400IU 维生素 D 的女性心理健康相关 QOL 明显低于每天摄入≥400IU 的女性。满足膳食维生素 D 推荐量可能是改善老年人 QOL 的一种方法。
