Sellitti T P, Huang A J, Schiffman J, Davis J L
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, FL 33101.
Am J Ophthalmol. 1993 Sep 15;116(3):297-301. doi: 10.1016/s0002-9394(14)71346-7.
We conducted a review to investigate the prevalence of human immunodeficiency virus (HIV), or acquired immunodeficiency syndrome (AIDS), in patients with herpes zoster ophthalmicus, as well as the incidence of acute retinal necrosis after herpes zoster ophthalmicus. All charts of patients seen at our institution between 1987 and 1992 with a primary diagnosis of herpes zoster ophthalmicus were reviewed. Of 112 patients with herpes zoster ophthalmicus, 29 (26%) had HIV or AIDS. All these patients were younger than 50 years at the time of diagnosis. Five of 29 (17%) immunocompromised patients had acute retinal necrosis after herpes zoster ophthalmicus. No acute retinal necrosis was identified in the nonimmunocompromised patients after herpes zoster ophthalmicus. We recommend that all patients younger than 50 years who have herpes zoster ophthalmicus at initial examination be tested for HIV. Additionally, HIV-infected patients should be monitored closely after herpes zoster ophthalmicus for development of acute retinal necrosis. Long-term oral prophylactic as well as initial high-dose intravenous acyclovir may be appropriate in HIV-infected individuals with herpes zoster.
我们进行了一项综述，以调查眼部带状疱疹患者中人类免疫缺陷病毒（HIV）或获得性免疫缺陷综合征（AIDS）的患病率，以及眼部带状疱疹后急性视网膜坏死的发生率。回顾了1987年至1992年间在我们机构就诊的、初步诊断为眼部带状疱疹的所有患者病历。在112例眼部带状疱疹患者中，29例（26%）患有HIV或AIDS。所有这些患者在诊断时年龄均小于50岁。29例免疫功能低下患者中有5例（17%）在眼部带状疱疹后发生急性视网膜坏死。在非免疫功能低下的眼部带状疱疹患者中未发现急性视网膜坏死。我们建议，所有初次检查时患有眼部带状疱疹且年龄小于50岁的患者都应进行HIV检测。此外，HIV感染患者在眼部带状疱疹后应密切监测是否发生急性视网膜坏死。长期口服预防性药物以及初始高剂量静脉注射阿昔洛韦可能适用于患有眼部带状疱疹的HIV感染个体。
