Berger S T, Mondino B J, Hoft R H, Donzis P B, Holland G N, Farley M K, Levenson J E
Ocular Inflammatory Disease Center, Jules Stein Eye Institute, Los Angeles, CA.
Am J Ophthalmol. 1990 Oct 15;110(4):395-403. doi: 10.1016/s0002-9394(14)77020-5.
Seven patients with documented Acanthamoeba keratitis were treated with prolonged and intensive triple antiamoebic therapy consisting of topical neomycin-polymyxin B-gramicidin, propamidine isethionate 0.1%, and miconazole nitrate 1%. Additionally, five patients were treated with topical corticosteroids. Six of seven patients were cured of Acanthamoeba keratitis with medical therapy alone, one patient required therapeutic penetrating keratoplasty to eradicate the infection. Two patients underwent penetrating keratoplasty to improve their vision after medical therapy. Our series differs from previous reports in that triple antiamoebic therapy was used in all seven patients and was successful in both early and advanced cases of Acanthamoeba keratitis. Prolonged and intensive topical therapy with these three antiamoebic drugs may be an effective mode of therapy for Acanthamoeba keratitis.
七名确诊为棘阿米巴角膜炎的患者接受了长期强化三联抗阿米巴治疗，治疗药物包括局部使用的新霉素-多粘菌素B-短杆菌肽、0.1%的依西酸丙脒和1%的硝酸咪康唑。此外，五名患者接受了局部皮质类固醇治疗。七名患者中有六名仅通过药物治疗就治愈了棘阿米巴角膜炎，一名患者需要进行治疗性穿透性角膜移植术以根除感染。两名患者在药物治疗后接受了穿透性角膜移植术以改善视力。我们的系列研究与之前的报告不同之处在于，所有七名患者均使用了三联抗阿米巴治疗，并且在棘阿米巴角膜炎的早期和晚期病例中均取得了成功。使用这三种抗阿米巴药物进行长期强化局部治疗可能是治疗棘阿米巴角膜炎的一种有效方法。
