Driebe W T, Stern G A, Epstein R J, Visvesvara G S, Adi M, Komadina T
Department of Ophthalmology, University of Florida College of Medicine, Gainesville 32610-0284.
Arch Ophthalmol. 1988 Sep;106(9):1196-201. doi: 10.1001/archopht.1988.01060140356031.
Clotrimazole is an antifungal agent that has been shown to have excellent in vitro activity against most strains of Acanthamoeba. We encountered four patients who developed Acanthamoeba keratitis while wearing contact lenses that had been stored in homemade saline. Their medical treatment regimens included the use of topical 1% clotrimazole. In two patients in whom conventional therapy failed, clotrimazole was successful in controlling recurrent infection following penetrating keratoplasty. Two other patients were treated with clotrimazole as well as propamidine isethionate and neomycin sulfate-polymyxin B sulfate-gramicidin from the outset, and had an excellent response to medical therapy. In those patients who found the commercially available cream uncomfortable, a 1% clotrimazole suspension formulated in artificial tears was used and found to be well tolerated.
克霉唑是一种抗真菌剂，已显示出对大多数棘阿米巴菌株具有出色的体外活性。我们遇到了四名在佩戴储存在自制盐水中的隐形眼镜时患上棘阿米巴角膜炎的患者。他们的治疗方案包括使用局部1%克霉唑。在两名传统治疗失败的患者中，克霉唑在穿透性角膜移植术后成功控制了反复感染。另外两名患者从一开始就接受了克霉唑以及羟乙磺酸丙脒和硫酸新霉素-硫酸多粘菌素B-短杆菌肽的治疗，对药物治疗反应良好。在那些觉得市售乳膏使用起来不舒服的患者中，使用了用人造泪液配制的1%克霉唑混悬液，发现耐受性良好。
