Moore M B, McCulley J P
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas 75235-9057.
Br J Ophthalmol. 1989 Apr;73(4):271-5. doi: 10.1136/bjo.73.4.271.
We examined and treated six patients with acanthamoeba keratitis associated with contact lens wear from 1981 to 1988. Five patients were treated with topical neomycin-polymyxin B-gramicidin (Neosporin) and propamidine isethionate (Brolene) drops. The patients were followed up for an average of 32 months (range 16-75 months). Two patients underwent penetrating keratoplasty at 22 and 26 months after the onset of symptoms and have maintained clear grafts with no evidence of recurrence. In four patients corneal infiltrates cleared on topical medication. All six patients have 6/6 best corrected vision. Early diagnosis and medical treatment alone can result in resolution of corneal infiltrates due to acanthamoebae. With this initial therapy we have had no treatment failures.
1981年至1988年期间，我们检查并治疗了6例与佩戴隐形眼镜相关的棘阿米巴角膜炎患者。5例患者接受了局部使用新霉素-多粘菌素B-短杆菌肽（新孢霉素）和依西酸丙脒（布洛内）滴眼液的治疗。患者平均随访32个月（范围16 - 75个月）。2例患者在症状出现后22个月和26个月接受了穿透性角膜移植术，移植片保持透明，无复发迹象。4例患者经局部用药后角膜浸润消退。所有6例患者最佳矫正视力均为6/6。早期诊断并单独进行药物治疗可使棘阿米巴引起的角膜浸润消退。采用这种初始治疗方法，我们没有治疗失败的情况。
