Department of Chemistry, College of Science, Shiraz University, Shiraz, Fars, Iran.
Amino Acids. 2012 Sep;43(3):1323-30. doi: 10.1007/s00726-011-1205-7. Epub 2011 Dec 31.
A novel double-step reduction procedure for the synthesis of gold nanoparticles (AuNPs) using amino acid ionic liquids has been employed. 1-Dodecyl-3-methyl imidazolium tryptophan ([C(12)mim]Trp) and 1-ethyl-3-methyl imidazolium tryptophan ([C(2)mim]Trp) were used for this synthesis. The synthesized AuNPs were characterized by UV-vis spectroscopy, transmission electron microscopy and dynamic light scattering. The behavior of these AuNPs were also probed in a biological media. It was proven that AuNPs synthesized at [C(12)mim]Trp have more stability than AuNPs synthesized at [C(2)mim]Trp due to the longer alkyl chain of the imidazolium moiety. The solubility test shows that the resultant AuNPs have a hydrophilic nature. Finally, it was seen that due to the presence of a biomolecule, namely Trp, in the structure of AuNPs protecting shell, higher stability and biocompatibility was achieved in the biological media.
采用氨基酸离子液体的新型两步还原法合成金纳米粒子（AuNPs）。使用 1-十二烷基-3-甲基咪唑啉色氨酸([C(12)mim]Trp)和 1-乙基-3-甲基咪唑啉色氨酸([C(2)mim]Trp)进行了这次合成。通过紫外-可见光谱、透射电子显微镜和动态光散射对合成的 AuNPs 进行了表征。还在生物介质中研究了这些 AuNPs 的行为。结果证明，由于咪唑啉部分的长烷基链，在[C(12)mim]Trp 中合成的 AuNPs 比在[C(2)mim]Trp 中合成的 AuNPs 具有更高的稳定性。溶解度测试表明，所得的 AuNPs 具有亲水性。最后，由于 AuNPs 保护壳结构中存在生物分子色氨酸，因此在生物介质中实现了更高的稳定性和生物相容性。
