Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Chemistry, College of Sciences, Shiraz University, Shiraz, 7194684795, Iran.
J Mater Sci Mater Med. 2018 Apr 18;29(5):48. doi: 10.1007/s10856-018-6053-5.
This work reports a novel reduction procedure for the synthesis of Gum Arabic (GA) capped-gold nanoparticles (AuNPs) in glucosammonium formate as a new ionic liquid. The GA coated AuNPs show good stability in physiological media. The synthesized AuNPs were characterized by UV-Vis spectroscopy, transmission electron microscopy, dynamic light scattering and X-ray diffraction analysis. These stable AuNPs are introduced as a new contrast agent for X-ray Computed Tomography (X-ray CT). These nanoparticles have higher contrasting properties than the commercial contrast agent, Visipaque. The precursors used (Gum Arabic and glucose based-ionic liquid) for synthesis of AuNPs are biocompatible and non-toxic.
这项工作报道了一种新型的金纳米粒子（AuNPs）还原方法，该方法以葡萄糖氨甲酸酯形式的新型离子液体为还原剂合成金纳米粒子。阿拉伯树胶（GA）包覆的 AuNPs 在生理介质中表现出良好的稳定性。所合成的 AuNPs 通过紫外可见光谱、透射电子显微镜、动态光散射和 X 射线衍射分析进行了表征。这些稳定的 AuNPs 被引入作为 X 射线计算机断层扫描（X-ray CT）的新型造影剂。与商业造影剂威视派克相比，这些纳米粒子具有更高的对比性能。用于 AuNPs 合成的前体（阿拉伯树胶和葡萄糖基离子液体）具有生物相容性和低毒性。
