Reeves Gloria M, Nijjar Gagan Virk, Langenberg Patricia, Johnson Mary A, Khabazghazvini Baharak, Sleemi Aamar, Vaswani Dipika, Lapidus Manana, Manalai Partam, Tariq Muhammad, Acharya Monika, Cabassa Johanna, Snitker Soren, Postolache Teodor T
Department of Psychiatry, Child and Adolescent Psychiatry Division, University of Maryland School of Medicine, 701 W Pratt Street, Baltimore, MD 21201, USA.
J Nerv Ment Dis. 2012 Jan;200(1):51-5. doi: 10.1097/NMD.0b013e31823e56ca.
The purpose of this study was to investigate possible rapid effects of light therapy on depressed mood in patients with seasonal affective disorder. Participants received 1 hour of bright light therapy and 1 hour of placebo dim red light in a randomized order crossover design. Depressed mood was measured at baseline and after each hour of light treatment using two self-report depression scales (Profile of Mood States-Depression-Dejection [POMS-D] subscale and the Beck Depression Inventory II [BDI-II]). When light effects were grouped for the two sessions, there was significantly greater reduction in self-report depression scores by -1.3 (p = 0.02) on the BDI-II and -1.2 (p = 0.02) on the POMS-D. A significant but modest improvement was detected after a single active light session. This is the first study, to our knowledge, to document an immediate improvement with light treatment using a placebo-controlled design with a clinical sample of depressed individuals.
本研究的目的是调查光疗法对季节性情感障碍患者抑郁情绪可能产生的快速影响。参与者采用随机交叉设计，接受1小时的强光疗法和1小时的安慰剂暗红光治疗。在基线时以及每次光照治疗1小时后，使用两个自我报告抑郁量表（情绪状态剖面图-抑郁-沮丧[POMS-D]子量表和贝克抑郁量表第二版[BDI-II]）测量抑郁情绪。当将两个疗程的光照效果合并时，BDI-II上的自我报告抑郁得分显著降低了-1.3（p = 0.02），POMS-D上降低了-1.2（p = 0.02）。在单次进行有效光照治疗后，检测到有显著但适度的改善。据我们所知，这是第一项使用安慰剂对照设计并以抑郁个体的临床样本记录光照治疗能立即改善症状的研究。
