硬脂酰辅酶 A 去饱和酶 1：在细胞炎症和应激中的作用。
Stearoyl CoA desaturase 1: role in cellular inflammation and stress.
机构信息
Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA.
出版信息
Adv Nutr. 2011 Jan;2(1):15-22. doi: 10.3945/an.110.000125. Epub 2011 Jan 10.
Abstract
Stearoyl CoA desaturase 1 (SCD1) catalyzes the rate-limiting step in the production of MUFA that are major components of tissue lipids. Alteration in SCD1 expression changes the fatty acid profile of these lipids and produces diverse effects on cellular function. High SCD1 expression is correlated with metabolic diseases such as obesity and insulin resistance, whereas low levels are protective against these metabolic disturbances. However, SCD1 is also involved in the regulation of inflammation and stress in distinct cell types, including β-cells, adipocytes, macrophages, endothelial cells, and myocytes. Furthermore, complete loss of SCD1 expression has been implicated in liver dysfunction and several inflammatory diseases such as dermatitis, atherosclerosis, and intestinal colitis. Thus, normal cellular function requires the expression of SCD1 to be tightly controlled. This review summarizes the current understanding of the role of SCD1 in modulating inflammation and stress.
摘要
硬脂酰辅酶 A 去饱和酶 1（SCD1）催化 MUFA 生成的限速步骤，MUFA 是组织脂质的主要成分。SCD1 表达的改变会改变这些脂质的脂肪酸谱，并对细胞功能产生多种影响。高 SCD1 表达与代谢疾病如肥胖和胰岛素抵抗相关，而低水平则可预防这些代谢紊乱。然而，SCD1 也参与调节不同细胞类型的炎症和应激，包括β细胞、脂肪细胞、巨噬细胞、内皮细胞和肌细胞。此外，SCD1 表达完全缺失与肝功能障碍和几种炎症性疾病有关，如皮炎、动脉粥样硬化和结肠炎。因此，正常的细胞功能需要严格控制 SCD1 的表达。本综述总结了目前对 SCD1 调节炎症和应激作用的认识。
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2
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6
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