Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA.
Am J Addict. 2012 Jan-Feb;21(1):5-10. doi: 10.1111/j.1521-0391.2011.00195.x. Epub 2011 Dec 15.
Completed suicide and nonfatal suicide-related outcomes (SROs), such as suicidal ideation and attempts, are heritable. A recent genetic association study in a sample of suicide victims reported a protective effect of the G allele of Asn40Asp (rs1799971) on risk for completed suicide. We examined the association of three OPRM1 single nucleotide polymorphisms (SNPs) (rs1799971, rs609148, and rs648893) with SRO in 426 European Americans, using GEE logistic regression analysis to examine the association of a lifetime history of SRO. There was no allelic association with the SRO phenotypes. A larger sample may be needed to identify risk variants that convey SRO risk. OPRM1 may not be important in the risk of SRO.
完成自杀和非致命性自杀相关结局（SROs），如自杀意念和尝试，是可遗传的。最近一项在自杀受害者样本中的遗传关联研究报告称，Asn40Asp（rs1799971）的 G 等位基因对完成自杀的风险有保护作用。我们使用 GEE 逻辑回归分析来检查三个 OPRM1 单核苷酸多态性（SNP）（rs1799971、rs609148 和 rs648893）与 426 名欧洲裔美国人的 SRO 之间的关联，以检查 SRO 病史的关联。SRO 表型与等位基因无关。可能需要更大的样本量来识别具有 SRO 风险的风险变异。OPRM1 可能对 SRO 的风险不重要。
