Department of Dermatology, National Taiwan University Hospital, Taipei, Taiwan.
Photodermatol Photoimmunol Photomed. 2012 Feb;28(1):6-11. doi: 10.1111/j.1600-0781.2011.00628.x.
To determine the efficacy of excimer light in the treatment vitiligo and to assess parameters affecting therapeutic results.
This retrospective study analyzed 227 patches of vitiligo in 142 patients. Treatment was performed twice weekly and treatment efficacy was assessed by two independent dermatologists. Patients who received less than 24 treatment sessions were excluded from the analysis of predictive factors for response.
Sixty-eight (30.0%) patches achieved more than 50% repigmentation, and 42 (18.5%) achieved more than 75% repigmentation. The mean treatment numbers to achieve any repigmentation and more than 50% repigmentation were 19.41 and 34.93, respectively. Fewer treatment sessions number, segmental lesions and absence of melasma were significant predictors for poor treatment response in multivariate analysis. Lesions on the hands/feet needed the highest dose and scalp lesions needed the highest number of treatment sessions to produce initial repigmentation.
Excimer light is a valuable treatment modality for both segmental and non-segmental vitiligo even in patients who have failed previous treatments. The number of treatment sessions needed to produce initial pigmentation may be higher than 30 for scalp lesions. There is a need to find other combination methods, both medical and surgical, to enhance its therapeutic efficacy.
评估准分子光治疗白癜风的疗效，并分析影响疗效的相关因素。
本回顾性研究共纳入 142 例患者的 227 处白癜风皮损。每周治疗 2 次，由 2 位独立的皮肤科医生评估疗效。对接受治疗次数少于 24 次的患者，不进行疗效预测因素分析。
68 处（30.0%）皮损色素恢复超过 50%，42 处（18.5%）皮损色素恢复超过 75%。达到任何程度色素恢复和超过 50%色素恢复的平均治疗次数分别为 19.41 次和 34.93 次。多因素分析显示，治疗次数少、节段性皮损、无黄褐斑是治疗反应差的显著预测因素。手部/足部皮损需要更高的剂量，头皮皮损需要更多的治疗次数才能产生初始色素恢复。
准分子光治疗白癜风疗效显著，不论皮损是否节段分布，既往治疗失败的患者也可获益。头皮皮损初始色素恢复所需的治疗次数可能超过 30 次。需要寻找其他联合治疗方法（包括药物和手术方法）以提高其疗效。
