Harran University, Sanliurfa, Turkey.
Redox Rep. 2012;17(5):214-8. doi: 10.1179/1351000212Y.0000000025.
Vitiligo is a common disorder that results in depigmented areas of the skin. The pathogenesis of the disease remains unclear, but oxidative stress is one suggested cause. Oxidative stress may be induced by increasing the generation of reactive oxygen species and other free radicals. The generation of reactive oxygen species is known to be associated with a decrease in antioxidant levels. This study examined oxidative stress index in active lesions of generalized vitiligo patients. We analysed serum levels of paraoxonase 1, arylesterase, catalase, ceruloplasmin, total antioxidant capacity, and oxidative stress index in patients with active lesions of generalized vitiligo, as well as in matched, healthy controls. Serum oxidants and oxidative stress indexes were higher, and serum antioxidants were lower, in vitiligo patients compared with healthy controls. Our findings suggest that oxidative stress may play an important role in the pathogenesis of vitiligo. Paraoxonase 1 can be used as an indicator in determining oxidative stress existent in the pathogenesis of vitiligo diseases.
白癜风是一种常见的疾病，导致皮肤出现色素脱失区域。该疾病的发病机制仍不清楚，但氧化应激是一种被提出的原因。氧化应激可能是由活性氧物种和其他自由基的生成增加引起的。已知活性氧物种的生成与抗氧化剂水平的降低有关。本研究检查了泛发性白癜风患者活动性病变中的氧化应激指数。我们分析了泛发性白癜风患者活动性病变患者以及匹配的健康对照组的血清对氧磷酶 1、芳基酯酶、过氧化氢酶、铜蓝蛋白、总抗氧化能力和氧化应激指数的水平。与健康对照组相比，白癜风患者的血清氧化剂和氧化应激指数较高，而血清抗氧化剂较低。我们的研究结果表明，氧化应激可能在白癜风的发病机制中起重要作用。对氧磷酶 1 可以作为确定白癜风疾病发病机制中存在氧化应激的指标。
