Larson D L, Kroll S, Jaffe N, Serure A, Goepfert H
Department of Plastic and Reconstructive Surgery, Medical College of Wisconsin, Milwaukee.
Am J Surg. 1990 Oct;160(4):348-51. doi: 10.1016/s0002-9610(05)80540-9.
The records of 50 selected pediatric patients who were treated and followed at M. D. Anderson Cancer Center were reviewed to study the late effects of nonsurgical treatment of cancer in children. There were 26 girls and 24 boys ranging in age between 2 months and 16 years. Patients with head and neck cancer received chemotherapy and radiotherapy for rhabdomyosarcoma (n = 27), retinoblastoma (n = 8), or nasopharynx cancer (n = 2). Median follow-up was 13 years. The most severe side effects were noted in the fields of radiation and included hypoplasia of the jaw, orbit, or hemi-face with varying degrees of atrophy of the overlying soft tissues. A wide range of endocrine, dental, and psychologic abnormalities was also documented. Since 1 in every 1,000 adults older than 20 years today is likely to be a survivor of childhood cancer, recommendations are made for this "new" class of patients whom the head and neck surgeon will be seeing in the future.
回顾了在MD安德森癌症中心接受治疗及随访的50例选定儿科患者的记录，以研究儿童癌症非手术治疗的晚期影响。其中有26名女孩和24名男孩，年龄在2个月至16岁之间。患有头颈癌的患者因横纹肌肉瘤（n = 27）、视网膜母细胞瘤（n = 8）或鼻咽癌（n = 2）接受了化疗和放疗。中位随访时间为13年。最严重的副作用出现在放疗区域，包括颌骨、眼眶或半侧面部发育不全，以及不同程度的覆盖软组织萎缩。还记录了广泛的内分泌、牙科和心理异常情况。鉴于如今每1000名20岁以上的成年人中就有1人可能是儿童癌症幸存者，针对头颈外科医生未来将会诊治的这类“新”患者群体提出了建议。
