Denys D, Kaste S C, Kun L E, Chaudhary M A, Bowman L C, Robbins K T
University of Tennessee Health Science Center, Memphis, USA.
Int J Pediatr Otorhinolaryngol. 1998 Sep 15;45(1):7-13. doi: 10.1016/s0165-5876(98)00028-7.
To determine whether radiation delivered to children treated for head and neck cancer causes deformity, we performed a quantitative analysis for craniofacial asymmetry. A total of 42 patients, with either rhabdomyosarcoma or nasopharyngeal carcinoma, treated between 1980 and 1991, were analyzed. Exclusions included 16 subjects, leaving 26 children of mixed race and gender with a median age at diagnosis of 13 years (range: 2-18) and a median age at follow-up of 4 years (range: 3-37). Data from 14 measurements of the cranium and facial skeleton, for which normative data exist, were recorded. Symmetry of the face and head were determined and each measurement was compared to age specific standards. Deviation occurred in the cranial vault, the anterior and mid-interorbital distances and lateral orbital wall length. Asymmetry existed in the medial and lateral orbital wall lengths and the zygomatic arches. We conclude that, children irradiated for head and neck malignancies, have significant alterations in some skeletal measurements indicative of treatment induced asymmetry and potential deformity.
为了确定接受头颈部癌症治疗的儿童所接受的辐射是否会导致畸形，我们对颅面不对称进行了定量分析。对1980年至1991年间接受治疗的42例横纹肌肉瘤或鼻咽癌患者进行了分析。排除16名受试者后，留下26名不同种族和性别的儿童，诊断时的中位年龄为13岁（范围：2至18岁），随访时的中位年龄为4岁（范围：3至37岁）。记录了来自颅骨和面部骨骼的14项有标准数据测量的结果。确定了面部和头部的对称性，并将每项测量结果与特定年龄标准进行了比较。颅顶、眶间前距离和眶间中距离以及眶外侧壁长度出现了偏差。眶内侧壁和外侧壁长度以及颧弓存在不对称。我们得出结论，接受头颈部恶性肿瘤放疗的儿童在一些骨骼测量上有显著改变，表明治疗导致了不对称和潜在畸形。
