Department of Clinical and Molecular Medicine, Sahlgrenska University Hospital, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden.
Scand Cardiovasc J. 2012 Feb;46(1):2-6. doi: 10.3109/14017431.2011.622783.
While long-term endurance exercise is known to increase cardiac biomarkers, only a few studies on short-term exercise and these markers have been reported. The aim of this study was to investigate the acute effects of a one-hour bicycle spinning on cardiac biomarkers in healthy individuals.
Serum levels of high-sensitive troponin T (TnT), creatinine kinase MB fraction (CK-MB), N-terminal pro-brain natriuretic peptide (NT-proBNP), creatinine kinase (CK) and myoglobin were measured at baseline, 1 and 24 hour after one hour of spinning exercise in ten healthy and fit (age 31.0 ± 6.6 years) individuals.
TnT doubled one hour post-exercise (All values ≤ 5 - 9.7 ± 6.0 ng/L, p < 0.001). Two individuals had TnT levels above upper reference limit, URL (20.7 and 20.2 ng/L, URL = 12 ng/L). Myoglobin levels increased 72% one hour post-exercise (38 ± 20 - 66 ± 41 mg/L, p < 0.02). TnT and myoglobin levels returned to baseline 24 hour post-exercise. Serum levels of CK-MB, NT-proBNP and CK were not significantly changed.
A single-bout of one-hour bicycle spinning transiently increases TnT and myoglobin in healthy subjects. Some subjects even have TnT release above URL. Thus, recently performed exercise also of short duration should be taken into consideration in the evaluation of acute chest pain with release of cardiac TnT.
虽然已知长期耐力运动可增加心脏生物标志物，但仅有少数关于短期运动和这些标志物的研究报告。本研究旨在探讨健康个体进行 1 小时自行车旋转运动对心脏生物标志物的急性影响。
在 10 名健康且体能良好的个体（年龄 31.0 ± 6.6 岁）进行 1 小时旋转运动后，分别于基线、1 小时和 24 小时测量高敏肌钙蛋白 T（TnT）、肌酸激酶 MB 同工酶（CK-MB）、氨基末端脑利钠肽前体（NT-proBNP）、肌酸激酶（CK）和肌红蛋白的血清水平。
TnT 在运动后 1 小时翻了一番（所有值均≤5-9.7 ± 6.0ng/L，p<0.001）。有 2 名个体的 TnT 水平超过上参考限（URL）（20.7 和 20.2ng/L，URL=12ng/L）。肌红蛋白水平在运动后 1 小时增加 72%（38 ± 20-66 ± 41mg/L，p<0.02）。TnT 和肌红蛋白水平在运动后 24 小时恢复至基线。CK-MB、NT-proBNP 和 CK 的血清水平没有明显变化。
单次 1 小时自行车旋转运动可使健康受试者的 TnT 和肌红蛋白短暂升高。有些患者的 TnT 释放甚至超过 URL。因此，在评估急性胸痛时应考虑最近进行的短暂运动导致的心脏 TnT 释放。
