Young W L, Prohovnik I, Schroeder T, Correll J W, Ostapkovich N
Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York.
Anesthesiology. 1990 Oct;73(4):637-43. doi: 10.1097/00000542-199010000-00009.
To document the comparability of cerebral blood flow (CBF) values determined by quantification of 133Xe washout after either intravenous or intracarotid administration, 12 patients undergoing elective carotid endarterectomy anesthetized with N2O/O2 and either isoflurane or halothane were studied. Scintillation counters were placed over the middle cerebral artery territory ipsilateral to the operated carotid artery. CBF was measured by the intravenous method during dissection of the carotid sheath and was calculated as the initial slope index from head washout curves collected for 11 min after injection of 10-20 mCi 133Xe in saline into a large vein. Immediately prior to carotid occlusion, CBF was determined by direct injection of 1 mCi 133Xe in saline into either the internal carotid artery or the common carotid artery with the external carotid artery occluded. For the intracarotid injections, the initial slope was calculated from the 1st min of washout. Data were analyzed by linear regression and analysis of variance. Values are expressed as mean +/- SD. The mean CBF for intravenous and intracarotid methods were both 29 +/- 10 ml.100 g-1.min-1. The correlation between CBF measured by intravenous and intracarotid methods was excellent and was described by the line y = x + 0.6, r = 0.92. We conclude that in the flow range studied, the intravenous technique may be applied to measure CBF in physiologically stable situations in which direct intracarotid injection is not feasible.
为了记录静脉注射或颈内动脉注射后通过量化133Xe洗脱所测定的脑血流量（CBF）值的可比性，我们对12例接受择期颈动脉内膜切除术的患者进行了研究，这些患者采用N2O/O2麻醉，并使用异氟烷或氟烷。将闪烁计数器置于手术侧颈动脉同侧的大脑中动脉区域上方。在解剖颈动脉鞘期间通过静脉法测量CBF，并将其计算为在向大静脉注射10 - 20 mCi溶解于生理盐水中的133Xe后收集11分钟的头部洗脱曲线的初始斜率指数。在即将进行颈动脉闭塞之前，通过将1 mCi溶解于生理盐水中的133Xe直接注射到颈内动脉或颈总动脉（颈外动脉已闭塞）来测定CBF。对于颈内动脉注射，初始斜率从洗脱的第1分钟计算得出。数据通过线性回归和方差分析进行分析。数值以平均值±标准差表示。静脉法和颈内动脉法的平均CBF均为29±10 ml·100 g-1·min-1。静脉法和颈内动脉法测量的CBF之间的相关性非常好，由直线y = x + 0.6，r = 0.92描述。我们得出结论，在所研究的血流范围内，静脉技术可应用于在直接颈内动脉注射不可行的生理稳定情况下测量CBF。
