Smith J K, Chi D S, Krish G, Reynolds S, Cambron G
Department of Internal Medicine, James H. Quillen College of Medicine, East Tennessee State University, Johnson City.
Ann Allergy. 1990 Oct;65(4):304-10.
Complement measurements of C1, C1q, C2, C3, C4, C5; the anaphylatoxins, C3a, C4a, and C5a; and total hemolytic activity of the classical and alternative pathways were made in 26 experienced adult runners before and after shortterm aerobic exercise. The baseline results were compared with those of nonexercising age-matched controls. In most subjects tested, running resulted in nanogram increases in C3a and C4a with corresponding decreases in the hemolytic activity of C4 (C4H). Baseline values of C3 and C4H were decreased significantly in runners when compared with nonexercising controls. Preliminary studies measuring the effect of exercise on C3a levels were also done in three asthmatic runners. Mean resting and postexercise levels, and exercise-induced increases in C3a anaphylatoxin in the asthmatic subjects were significantly higher than in the nonasthmatic subjects. The findings indicate that short-term exercise results in the activation of C3 and C4 and subsequent generation of C3a and C4a anaphylatoxins, and suggest that both activation of the classical pathway of complement and a selective downregulation of C3 production may occur in persons regularly engaged in aerobic exercise. The exaggerated generation of C3a by asthmatic subjects during exercise raises the possibility that anaphylatoxins play an etiologic role in exercise-induced asthma.
在26名有经验的成年跑步者进行短期有氧运动前后，对其C1、C1q、C2、C3、C4、C5进行补体测量；对过敏毒素C3a、C4a和C5a进行测量；并对经典途径和替代途径的总溶血活性进行测量。将基线结果与年龄匹配的非运动对照组的结果进行比较。在大多数受试对象中，跑步导致C3a和C4a增加纳克，同时C4（C4H）的溶血活性相应降低。与非运动对照组相比，跑步者的C3和C4H基线值显著降低。还对三名哮喘跑步者进行了测量运动对C3a水平影响的初步研究。哮喘受试者的平均静息水平和运动后水平以及运动诱导的C3a过敏毒素增加显著高于非哮喘受试者。研究结果表明，短期运动导致C3和C4激活以及随后产生C3a和C4a过敏毒素，并表明经常进行有氧运动的人可能会出现补体经典途径的激活和C3产生的选择性下调。哮喘受试者在运动期间C3a的过度产生增加了过敏毒素在运动诱发哮喘中起病因作用的可能性。
