Laboratory of Epidemiology and National Institute for Translational Medicine Health Sciences Unit, University of Extremo Sul Catarinense (UNESC), Criciúma, Santa Catarina.
Int J Gynecol Cancer. 2012 Mar;22(3):343-7. doi: 10.1097/IGC.0b013e31823c712e.
We performed a systematic review and meta-analyses to estimate the prevalence of human papillomavirus (HPV) in breast carcinoma and to explore the reasons for the ongoing controversies about this issue.
A comprehensive search of the Cochrane Library, MEDLINE, CANCERLIT, LILACS, and EMBASE databases was performed for papers published from January 1990 to January 2011. The medical subject heading terms were searched for the following: breast neoplasm, breast lesions, breast cancer, and HPV or human papillomavirus. Statistical analysis was performed using REVMAN 5.0.
Twenty-nine primary studies, including 2211 samples, were analyzed. Overall, HPV prevalence in patients with breast cancer was 23.0% (95% CI, 21.2%-24.8%). The prevalence of HPV ranged from 13.4% (95% CI, 10.2%-16%) in Europe to 42.9% (95% CI, 36.4%-49.4%) in North America and Australia. The prevalence of HPV in controls was 12.9%. Combinations of 9 case-control studies showed that breast cancer was associated with HPV (odds ratio, 5.9; 95% CI, 3.26-10.67).
We found a high prevalence of HPV DNA in breast cancer. There is strong evidence to suggest that HPV has an important role in the development of breast cancer.
我们进行了系统评价和荟萃分析，以评估人乳头瘤病毒（HPV）在乳腺癌中的流行情况，并探讨该问题持续存在争议的原因。
对 Cochrane 图书馆、MEDLINE、CANCERLIT、LILACS 和 EMBASE 数据库自 1990 年 1 月至 2011 年 1 月发表的文献进行了全面检索。使用医学主题词搜索以下内容：乳腺肿瘤、乳腺病变、乳腺癌和 HPV 或人乳头瘤病毒。使用 REVMAN 5.0 进行统计分析。
共分析了 29 项原始研究，包括 2211 个样本。总体而言，乳腺癌患者中 HPV 的流行率为 23.0%（95%CI，21.2%-24.8%）。HPV 的流行率从欧洲的 13.4%（95%CI，10.2%-16%）到北美和澳大利亚的 42.9%（95%CI，36.4%-49.4%）不等。对照组 HPV 的流行率为 12.9%。9 项病例对照研究的组合表明，乳腺癌与 HPV 相关（比值比，5.9；95%CI，3.26-10.67）。
我们发现乳腺癌中 HPV DNA 的高流行率。有强有力的证据表明 HPV 在乳腺癌的发生发展中起重要作用。
