缺血组织代谢的磁共振特征
Magnetic resonance characterization of ischemic tissue metabolism.
作者信息
Cheung Jerry S, Wang Xiaoying, Zhe Sun Phillip
机构信息
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
出版信息
Open Neuroimag J. 2011;5:66-73. doi: 10.2174/1874440001105010066. Epub 2011 Nov 4.
Magnetic resonance imaging (MRI) and spectroscopy (MRS) are versatile diagnostic techniques capable of characterizing the complex stroke pathophysiology, and hold great promise for guiding stroke treatment. Particularly, tissue viability and salvageability are closely associated with its metabolic status. Upon ischemia, ischemic tissue metabolism is disrupted including altered metabolism of glucose and oxygen, elevated lactate production/accumulation, tissue acidification and eventually, adenosine triphosphate (ATP) depletion and energy failure. Whereas metabolism impairment during ischemic stroke is complex, it may be monitored non-invasively with magnetic resonance (MR)-based techniques. Our current article provides a concise overview of stroke pathology, conventional and emerging imaging and spectroscopy techniques, and data analysis tools for characterizing ischemic tissue damage.
磁共振成像（MRI）和波谱学（MRS）是多功能诊断技术，能够描绘复杂的中风病理生理学特征，对指导中风治疗具有巨大潜力。特别是，组织活力和可挽救性与其代谢状态密切相关。缺血时，缺血组织代谢会受到干扰，包括葡萄糖和氧代谢改变、乳酸生成/积累增加、组织酸化，最终导致三磷酸腺苷（ATP）耗竭和能量衰竭。虽然缺血性中风期间的代谢损害很复杂，但可以通过基于磁共振（MR）的技术进行无创监测。我们当前的文章简要概述了中风病理学、传统和新兴的成像及波谱学技术，以及用于表征缺血性组织损伤的数据分析工具。
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