Woods R D
Am J Vet Res. 1979 Jan;40(1):108-10.
Swine exposed to attenuated transmissible gastroenteritis virus had higher virus-neutralizing antibody titers than did swine exposed to virulent virus. The cellular response, measured by the direct leukocyte migration-inhibition (LMI) procedure, was greater in swine exposed to virulent virus than in swine exposed to the attenuated virus. Leukocytes from exposed swine were inhibited more in the LMI procedure in the presence of the homologeous sensitizing antigen than in the presence of the heterologous viral antigen. The humoral response measured by virus neutralizing reached a peak 21 days after exposure, and the cellular response measured by LMI reached a peak 28 days after exposure.
接触减毒传染性胃肠炎病毒的猪比接触强毒病毒的猪具有更高的病毒中和抗体滴度。通过直接白细胞迁移抑制(LMI)程序测量的细胞反应,在接触强毒病毒的猪中比在接触减毒病毒的猪中更大。在同源致敏抗原存在下,暴露猪的白细胞在LMI程序中的抑制作用比在异源病毒抗原存在下更强。通过病毒中和测量的体液反应在接触后21天达到峰值,通过LMI测量的细胞反应在接触后28天达到峰值。