Woods R D, Wesley R D
Am J Vet Res. 1986 Jun;47(6):1239-42.
Twelve pregnant sows were inoculated oral-nasally 8 weeks before farrowing with attenuated transmissible gastroenteritis virus (TGEV), tissue culture-adapted canine coronavirus (CCV), or fluids from mock-infected culture (controls). A 2nd dose of the same inoculum, one-half oral-nasally and one-half intramammarily, was given 6 weeks later. Neutralizing antibodies for TGEV and CCV were demonstrated in sera, colostrum, and milk whey from the virus-vaccinated sows. Homologous geometric mean neutralizing titers were generally 4-fold higher than were heterologous titers. After challenge exposure of the nursing pigs with virulent TGEV, average morbidity and mortality for the pigs were 81% and 34% (mortality range = 11% to 63%), respectively, in the TGEV-vaccinated group; 83% and 39% (mortality range = 15% to 83%), respectively, in the CCV-vaccinated group; and 97% and 84% (mortality range = 78% to 100%), respectively, in the controls. Seemingly, sera from swine exposed to CCV could test serologically positive for TGEV-neutralizing antibody, and TGEV and CCV share at least 1 common neutralizing determinant that may be involved in protection.
12头怀孕母猪在分娩前8周经口鼻接种减毒的传染性胃肠炎病毒（TGEV）、适应组织培养的犬冠状病毒（CCV）或 mock 感染培养物的液体（对照组）。6周后，再次接种相同的接种物，一半经口鼻接种，一半经乳腺接种。在接种病毒的母猪的血清、初乳和乳清中检测到针对TGEV和CCV的中和抗体。同源几何平均中和滴度通常比异源滴度高4倍。在用强毒TGEV攻击哺乳仔猪后，TGEV疫苗接种组仔猪的平均发病率和死亡率分别为81%和34%（死亡率范围=11%至63%）；CCV疫苗接种组分别为83%和39%（死亡率范围=15%至83%）；对照组分别为97%和84%（死亡率范围=78%至100%）。显然，接触CCV的猪的血清在TGEV中和抗体检测中可能呈血清学阳性，并且TGEV和CCV至少共享1个可能参与保护作用的共同中和决定簇。
