Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo, 200, 00128 Rome, Italy.
Stem Cells Int. 2012;2012:528359. doi: 10.1155/2012/528359. Epub 2011 Dec 13.
Meniscal injuries in the vascularized peripheral part of the meniscus have a better healing potential than tears in the central avascular zone because meniscal healing principally depends on its vascular supply. Several biological strategies have been proposed to enhance healing of the avascular area of the meniscus: abrasion therapy, fibrin clot, organ culture, cell therapy, and applications of growth factors. However, data are too heterogeneous to achieve definitive conclusions on the use of these techniques for routine management of meniscal lesions. Although most preclinical and clinical studies are very promising, they are still at an experimental stage. More prospective randomised controlled trials are needed to compare the different techniques for clinical results, applicability, and cost-effectiveness.
半月板血管化外周部分的半月板损伤比中央无血管区的撕裂具有更好的愈合潜力，因为半月板的愈合主要取决于其血管供应。已经提出了几种生物学策略来增强半月板无血管区的愈合：磨蚀疗法、纤维蛋白凝块、器官培养、细胞疗法和生长因子的应用。然而，数据过于多样化，无法就这些技术在半月板损伤常规治疗中的应用得出明确的结论。尽管大多数临床前和临床研究都非常有前景，但它们仍处于实验阶段。需要更多的前瞻性随机对照试验来比较不同技术的临床结果、适用性和成本效益。
