编码乙型肝炎表面抗原中蛋白的重组痘苗病毒的启动效应
Priming effect of recombinant vaccinia virus coding for the middle hepatitis B surface antigen.
作者信息
Hamsíková E, Závadová H, Kutinová L, Ludvíková V, Krchnák V, Némecková S, Vonka V
机构信息
Department of Experimental Virology, Institute of Sera and Vaccines, Prague, Czechoslovakia.
出版信息
Arch Virol. 1990;113(3-4):283-9. doi: 10.1007/BF01316681.
PMID:2222186
Abstract
Recombinant vaccinia virus expressing the middle hepatitis B virus surface antigen was incapable of inducing marked antibody response against the S and pre-S2 antigenic specifities in mice. However, mice immunized with this virus produced antibodies to both these antigens after the following administration of subtreshold doses of plasmatic hepatitis B surface antigen.
摘要
表达乙型肝炎病毒表面中蛋白抗原的重组痘苗病毒无法在小鼠中诱导出针对S抗原和前S2抗原特异性的显著抗体反应。然而，用这种病毒免疫的小鼠在随后接种亚阈值剂量的血浆乙型肝炎表面抗原后，产生了针对这两种抗原的抗体。
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