重组痘苗病毒：针对多种病原体的免疫接种。
Recombinant vaccinia virus: immunization against multiple pathogens.
作者信息
Perkus M E, Piccini A, Lipinskas B R, Paoletti E
出版信息
Science. 1985 Sep 6;229(4717):981-4. doi: 10.1126/science.2992092.
PMID:2992092
Abstract
The coding sequences for the hepatitis B virus surface antigen, the herpes simplex virus glycoprotein D, and the influenza virus hemagglutinin were inserted into a single vaccinia virus genome. Rabbits inoculated intravenously or intradermally with this polyvalent vaccinia virus recombinant produced antibodies reactive to all three authentic foreign antigens. In addition, the feasibility of multiple rounds of vaccination with recombinant vaccinia virus was demonstrated.
摘要
将乙型肝炎病毒表面抗原、单纯疱疹病毒糖蛋白D和流感病毒血凝素的编码序列插入单个痘苗病毒基因组中。用这种多价痘苗病毒重组体经静脉或皮内接种的兔子产生了对所有三种天然外源抗原都有反应的抗体。此外，还证明了用重组痘苗病毒进行多轮接种的可行性。
Zotero 插件