Trufakin V A, Shmakov A N
Arkh Anat Gistol Embriol. 1990 May;98(5):73-9.
By means of the radioautographic method the state of cellular restoration of the gastric epithelium has been estimated after administration of syngenic lymphocytes to mice. Under conditions of physiological regeneration T-lymphocytes are able to inhibit proliferation of the epithelial cells and to limit the size of the proliferation zone in crypts. The inhibition degree of the proliferative activity depends on the doze of the T-cells administered. In order to demonstrate their activity, T-cells do not need DNA and RNA synthesis de novo. At the same time, protein synthesis is necessary; it occurs on long-living mRNA lymphocytes. The T-lymphocyte action is reversible at the tissue, but not at the cellular level. The mechanism of decreasing cell reproduction under effect of T-lymphocytes is described. In the process of lymphoid regulation of the cellular restoration in the intestinal epithelium changes in the size of the proliferative pool play the main role.
通过放射自显影法，在给小鼠注射同基因淋巴细胞后，评估了胃上皮细胞的恢复状态。在生理再生条件下，T淋巴细胞能够抑制上皮细胞的增殖，并限制隐窝中增殖区的大小。增殖活性的抑制程度取决于所注射T细胞的剂量。为了展现其活性，T细胞不需要重新进行DNA和RNA合成。与此同时，蛋白质合成是必需的；它发生在寿命较长的mRNA淋巴细胞上。T淋巴细胞的作用在组织水平上是可逆的，但在细胞水平上不可逆。描述了T淋巴细胞作用下细胞繁殖减少的机制。在肠道上皮细胞恢复的淋巴细胞调节过程中，增殖池大小的变化起主要作用。
