起始RNA聚合酶II和TIPs作为增强子活性和组织特异性的标志。
Initiating RNA polymerase II and TIPs as hallmarks of enhancer activity and tissue-specificity.
作者信息
Koch Frederic, Andrau Jean-Christophe
机构信息
Centre d'Immunologie de Marseille-Luminy, Campus de Luminy, Marseille, France.
出版信息
Transcription. 2011 Nov-Dec;2(6):263-8. doi: 10.4161/trns.2.6.18747. Epub 2011 Nov 1.
Abstract
In past years, many efforts were invested to define epigenetic features associated with enhancers of transcription. We propose that both transcription initiation and the H3K4me3 histone modification are among the best hallmarks of active enhancers in several primary tissues and extend the concept of large transcription initiation platforms (TIPs).
摘要
在过去几年中，人们投入了大量精力来定义与转录增强子相关的表观遗传特征。我们提出，转录起始和H3K4me3组蛋白修饰都是几种主要组织中活跃增强子的最佳标志，并扩展了大型转录起始平台（TIPs）的概念。
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