Department of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854, USA.
Adv Mater. 2012 Feb 7;24(6):733-9. doi: 10.1002/adma.201103348. Epub 2012 Jan 2.
Kinetically assembled nanoparticles are fabricated from an advanced class of bioactive macromolecules that have potential utility in counteracting atherosclerotic plaque development via receptor-level blockage of inflammatory cells. In contrast to micellar analogs that exhibit poor potency and structural integrity under physiologic conditions, these kinetic nanoparticle assemblies maintain structural stability and demonstrate superior bioactivity in mediating oxidized low-density lipoprotein (oxLDL) uptake in inflammatory cells.
通过在受体水平阻断炎症细胞,动力学组装纳米颗粒是由一类先进的生物活性大分子制造而成,具有对抗动脉粥样硬化斑块发展的潜在应用价值。与在生理条件下表现出低效力和结构完整性差的胶束类似物相比,这些动力学纳米颗粒组装体在介导炎症细胞中氧化低密度脂蛋白(oxLDL)摄取方面保持结构稳定性并表现出优异的生物活性。