Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
J Hum Lact. 2012 May;28(2):189-95. doi: 10.1177/0890334411424727. Epub 2012 Jan 4.
The aim of the present study was to examine the association between depressive symptoms in pregnancy and the concentration of long-chain polyunsaturated fatty acids (LCPUFAs) in breast milk. Women (n = 287) enrolled in the Pregnancy, Infection, and Nutrition Study completed the Center for Epidemiologic Studies Depression Scale in pregnancy (< 20 and 24-29 weeks) and had LCPUFAs measured in breast milk (4 months postpartum). Multiple linear regression was used to examine associations between depressive symptoms and breast milk LCPUFAs. Increasing depressive symptoms at < 20 weeks were associated with lower docosahexaenoic acid concentrations (adjusted β = -1.15, 95% confidence interval = -2.12, -0.19). No similar associations were observed with other fatty acids nor between symptoms at 24-29 weeks and LCPUFAs. Depressive symptoms, even in the subclinical range, early in pregnancy are inversely associated with breast milk docosahexaenoic acid. This may have implications for the timing of screening and interventions for perinatal depression and the nutritional value of breast milk.
本研究旨在探讨妊娠期间抑郁症状与母乳中长链多不饱和脂肪酸（LCPUFAs）浓度之间的关系。参与妊娠、感染和营养研究的女性（n=287）在妊娠期间（<20 周和 24-29 周）完成了流行病学研究中心抑郁量表，并在产后 4 个月测量了母乳中的 LCPUFAs。采用多元线性回归分析抑郁症状与母乳 LCPUFAs 之间的关系。<20 周时抑郁症状增加与二十二碳六烯酸浓度降低相关（调整后β=-1.15，95%置信区间=-2.12，-0.19）。其他脂肪酸或 24-29 周时的症状与 LCPUFAs 之间均无类似关联。妊娠早期即使是亚临床范围的抑郁症状也与母乳二十二碳六烯酸呈负相关。这可能对围产期抑郁的筛查和干预时间以及母乳的营养价值产生影响。
