Tekle Esayas, Gelaw Yemataw, Asrie Fikir
Department of Medical Laboratory Sciences, Institute of Health Sciences, Wallaga University, Nekemte, Ethiopia.
Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
J Blood Med. 2022 Sep 29;13:525-536. doi: 10.2147/JBM.S379841. eCollection 2022.
Hematological profiles are measurable indices of blood that can be used to identify and monitor some pathological and physiological abnormalities. Oral contraceptives are one of the factors which may exert an influence on hematological laboratory test results and have a critical importance. Therefore, the main goal of this review was to evaluate the hematologic profile alterations brought on by the use of oral contraceptives. Accordingly, even though there were studies that showed no significant difference, most of the oral contraceptive users had higher hemoglobin, platelet, and erythrocyte counts than non-users. Other erythrocyte metrics, such as mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration and red cell dispersion width, did not significantly change. Moreover, leukocyte count and leukocyte differential count had no significant change among the oral contraceptive users in comparison to non-users. Oral contraceptive users typically have shorter prothrombin times, activated partial thromboplastin times, thrombin times, and greater levels of fibrinogen and D-dimer compared to non-users. However, this review is a narrative review and did not show the pooled effect of oral contraceptives on these hematological parameters. Therefore, it is recommended to do systematic and meta-analysis to determine the pooled effect of oral contraceptives.
血液学指标是可用于识别和监测某些病理和生理异常的血液可测量指标。口服避孕药是可能影响血液学实验室检测结果且至关重要的因素之一。因此，本综述的主要目的是评估使用口服避孕药引起的血液学指标变化。相应地，尽管有研究表明无显著差异，但大多数口服避孕药使用者的血红蛋白、血小板和红细胞计数高于非使用者。其他红细胞指标，如平均红细胞体积、平均红细胞血红蛋白、平均红细胞血红蛋白浓度和红细胞分布宽度，无显著变化。此外，与非使用者相比，口服避孕药使用者的白细胞计数和白细胞分类计数无显著变化。与非使用者相比，口服避孕药使用者的凝血酶原时间、活化部分凝血活酶时间、凝血酶时间通常更短，纤维蛋白原和D - 二聚体水平更高。然而，本综述是一篇叙述性综述，未显示口服避孕药对这些血液学参数的综合影响。因此，建议进行系统评价和荟萃分析以确定口服避孕药的综合影响。
