Wagner J G, Wilkinson P K, Ganes D A
College of Pharmacy, University of Michigan, Ann Arbor 48109.
Alcohol Alcohol. 1990;25(4):379-84.
Capillary blood alcohol concentrations (BAL) measured in 22 young adult male volunteers each of whom received three different treatments of alcohol (total N = 66) have been related quantitatively to the dose of alcohol ingested. Linear regression with reasonably homogeneous variances have been found when the BAL at 2, 2.5 and 3 hr are divided by the person's body weight and plotted versus the g/kg (D/W) dose. Error analysis indicated that the least error in the predicted dose (D/W) was obtained for BAL measured at 2 hr post dosing. In the latter case the mean absolute error was 6.23%, 59% of the errors were within +/- 5% and 88% of the errors were within +/- 10%.
对22名年轻成年男性志愿者进行了测量,每人接受三种不同的酒精处理(总数N = 66),毛细血管血酒精浓度(BAL)已与摄入的酒精剂量进行了定量关联。当将2、2.5和3小时时的BAL除以个体体重,并与克/千克(D/W)剂量作图时,发现具有合理均匀方差的线性回归。误差分析表明,给药后2小时测量的BAL在预测剂量(D/W)中获得的误差最小。在后一种情况下,平均绝对误差为6.23%,59%的误差在±5%以内,88%的误差在±10%以内。