Posnett D N
Department of Medicine, Cornell University Medical College, New York, NY 10021.
Immunol Today. 1990 Oct;11(10):368-73. doi: 10.1016/0167-5699(90)90143-w.
A central problem confronting the immune system is how to discriminate among vast numbers of antigens. Novel genetic ploys that aid the discriminative process, including complex gene rearrangements (in antibody and T-cell receptor (TCR) genes) and extensive allelic polymorphism (in major histocompatibility complex (MHC) genes), have been described. Recent evidence has suggested a further level of diversity; TCR V gene allelic variation. In this article David Posnett summarizes evidence in favour of this possibility and speculates on the possible functional consequences of TCR allelism.
免疫系统面临的一个核心问题是如何在大量抗原中进行区分。人们已经描述了有助于这一区分过程的新的遗传策略，包括复杂的基因重排（抗体和T细胞受体（TCR）基因中）和广泛的等位基因多态性（主要组织相容性复合体（MHC）基因中）。最近的证据表明了另一个层面的多样性；TCR V基因的等位基因变异。在本文中，大卫·波斯内特总结了支持这种可能性的证据，并推测了TCR等位基因可能产生的功能后果。
