State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Mol Carcinog. 2013 May;52(5):387-91. doi: 10.1002/mc.21869. Epub 2012 Jan 6.
p73, a structural and functional homolog of p53, plays an important role in tumor carcinogenesis. Previous studies have suggested that the association between the p73 G4C14-to-A4T14 polymorphism and the risk of lung cancer, but the results have not been entirely consistent. We examined whether the p73 G4C14-to-A4T14 polymorphism was related to the risk of developing lung cancer in a Chinese population. The p73 G4C14-to-A4T14 polymorphism was genotyped in 293 lung cancer patients and 380 cancer-free controls of Han nationality in North China using PCR-RFLP. Multivariate logistic regression analysis was used to calculate adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs). We observed that compared with the GC/GC genotype, the genotypes containing AT allele (GC/AT + AT/AT genotypes) were associated with significantly increased susceptibility to lung cancer (OR, 1.48; 95% CI, 1.08-2.02; P = 0.014). In addition, compared with the GC/GC genotype, the GC/AT genotype was also significantly associated with increased susceptibility to lung cancer (OR, 1.46; 95% CI, 1.06-2.02; P = 0.046). Our findings suggest that the p73 G4C14-to-A4T14 polymorphism contributes to the risk of developing lung cancer in Chinese population.
p73 是 p53 的结构和功能同源物，在肿瘤发生中发挥重要作用。先前的研究表明，p73 G4C14 到 A4T14 多态性与肺癌风险之间存在关联，但结果并非完全一致。我们研究了 p73 G4C14 到 A4T14 多态性是否与中国人群肺癌发病风险相关。采用 PCR-RFLP 法检测华北地区汉族 293 例肺癌患者和 380 例对照的 p73 G4C14 到 A4T14 多态性。采用多变量 logistic 回归分析计算调整后的比值比（OR）及其 95%置信区间（95%CI）。结果发现，与 GC/GC 基因型相比，携带 AT 等位基因的基因型（GC/AT+AT/AT 基因型）与肺癌易感性显著增加相关（OR=1.48，95%CI：1.08-2.02，P=0.014）。此外，与 GC/GC 基因型相比，GC/AT 基因型也与肺癌易感性显著增加相关（OR=1.46，95%CI：1.06-2.02，P=0.046）。这些发现表明，p73 G4C14 到 A4T14 多态性可能增加中国人群肺癌的发病风险。
