Association between p73 RS2273953 to RS1801173 polymorphism and risk of lung cancer: a meta-analysis of 2,897 cases and 3,317 controls.

BACKGROUND

Lung cancer is one of the most common and deadly cancers in humans. , a member of the family, is a vital gene for the carcinogenesis of lung cancer. Single nucleotide polymorphism (SNP) of gene may affect the risk of lung cancer. Therefore, we performed a meta-analysis of SNP and lung cancer risk using the most recent data.

METHODS

A total of 1407 articles from EMBASE, Web of science, PubMed and Chinese National Knowledge Infrastructure (CNKI) databases were identified initially from the search. A meta-analysis of the association between polymorphism and lung cancer risk was performed based on various genetic models and by type of lung cancer and race.

RESULTS

Seven articles published in either English or Chinese with English abstract were eventually selected for final analysis. The total pooled population included 6214 subjects (2,897 cases and 3,317 controls). The results showed that RS2273953 to RS1801173 polymorphism was associated with increased risk of lung cancer in Caucasians but not in Asians. Within Asians, those with GC/GC may have an increased risk for squamous carcinoma compared to those with GC/AT+AT/AT polymorphism.

CONCLUSIONS

Our analysis suggested a lack of association between RS2273953 to RS1801173 polymorphism and risk of lung cancer overall. However, patients with GC/GC polymorphism showed an increased risk for squamous carcinoma in the lung compared to those with GC/AT+AT/AT in Asians.