Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1 Friendship Road, Yuanjiagang, Yuzhong District, Chongqing, 400016, People's Republic of China.
Med Oncol. 2012 Dec;29(5):3216-21. doi: 10.1007/s12032-012-0240-x. Epub 2012 Apr 26.
The aim of this study was to evaluate the association of p73 G4C14-A4T14 polymorphisms with susceptibility to breast cancer in Chongqing women of Han Nationality in China. In a case-control study, single-nucleotide polymorphisms of p73 G4C14-A4T14 at exon 2 were genotyped by Sequenom MassArray(®) iPLEX GOLD System in 170 patients with breast cancer and 178 healthy controls. Data were analyzed via t test, Chi-square test, and logistic regression analysis. The distribution of p73 genotypes and allelotypes had no significant difference between patients with breast cancer and healthy controls (χ(2) = 2.750, P = 0.253; χ(2) = 2.195, P = 0.138). More risk of developing triple negative breast cancer (TNBC) was found in the individuals who carried with GC/GC genotype than individuals carried with GC/AT and AT/AT genotypes (OR = 2.99; 95 % CI, 1.30-6.89; P = 0.010). p73 G4C14-A4T14 polymorphisms are closely associated with the increased risk for TNBC in Chongqing women of Han Nationality in China; GC/GC genotype is susceptible genotype for TNBC in Chongqing women of Han Nationality in China. The patients with breast cancer who carried with GC/GC genotype may have bad prognosis. Additional larger studies are required to confirm these findings.
本研究旨在评估 p73 G4C14-A4T14 多态性与中国重庆汉族女性乳腺癌易感性的关系。采用病例对照研究，应用Sequenom MassArray(®) iPLEX GOLD 系统对 170 例乳腺癌患者和 178 例健康对照者的 p73 G4C14-A4T14 外显子 2 单核苷酸多态性进行基因分型。采用 t 检验、卡方检验和 logistic 回归分析进行数据分析。乳腺癌患者和健康对照组的 p73 基因型和等位基因分布无显著差异（χ²=2.750，P=0.253；χ²=2.195，P=0.138）。携带 GC/GC 基因型的个体发生三阴性乳腺癌（TNBC）的风险高于携带 GC/AT 和 AT/AT 基因型的个体（OR=2.99；95%CI，1.30-6.89；P=0.010）。p73 G4C14-A4T14 多态性与中国重庆汉族女性 TNBC 风险增加密切相关；GC/GC 基因型是中国重庆汉族女性 TNBC 的易感基因型。携带 GC/GC 基因型的乳腺癌患者可能预后不良。需要进一步开展更大规模的研究来验证这些发现。
