Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663N, Zhongshan Road, Shanghai 200062, PR China.
Chem Commun (Camb). 2012 Feb 11;48(13):1919-21. doi: 10.1039/c2cc17140f. Epub 2012 Jan 9.
We report the first example of highly enantioselective organocatalytic synthesis of 3-difluoroalkyl substituted 3-hydroxyoxindoles. The total synthesis of the difluoro analogue of convolutamydine E was achieved by this method.
我们报道了首例高对映选择性的有机催化合成 3-二氟烷基取代的 3-羟基氧吲哚的例子。通过这种方法实现了 convovulotamydine E 的二氟类似物的全合成。
