Kalaiselvan V, Kalaivani M, Vijayakumar A, Sureshkumar K, Venkateskumar K
Indian Pharmacopoeia Commission, Sector 23, Raj Nagar, Ghaziabad- 201002, Uttar Pradesh, India .
Pharmacogn Rev. 2010 Jul;4(8):111-7. doi: 10.4103/0973-7847.70900.
Isoflavones, the most abundant phytoestrogens in Soy beans, are structurally similar to 17beta-estradiol. The antioxidant property of the soy isoflavones, namely, genistein and daidzein is well established in different experimental models and also in clinical studies. The compounds have been found effective in the management of diabetes by acting on peroxisome proliferator-activated receptors. It reduces the risk of coronary heart disease by reducing the level of low-density lipoprotein and triglycerides. Soy isoflavones have the potential in the treatment of osteoporosis to act on osteoclasts further to inhibit tyrosine kinase. Among the soy isoflavones, genistein is the potential compound found effective in the treatment of cancer by acting on androgen receptor further to inhibit tyrosine kinases. In this article, various aspects of the diverse biological activities of soy isoflavones and their potential clinical implications with mechanism of action, especially in the treatment and prevention of diabetes, cardiovascular diseases, cancer, osteoporosis, neuroprotection, and also future area of research on soy isoflavones are reviewed and discussed.
异黄酮是大豆中含量最为丰富的植物雌激素，其结构与17β-雌二醇相似。大豆异黄酮（即染料木黄酮和黄豆苷元）的抗氧化特性在不同实验模型及临床研究中均已得到充分证实。这些化合物已被发现可通过作用于过氧化物酶体增殖物激活受体来有效控制糖尿病。它通过降低低密度脂蛋白和甘油三酯水平来降低冠心病风险。大豆异黄酮在治疗骨质疏松症方面具有潜力，可进一步作用于破骨细胞以抑制酪氨酸激酶。在大豆异黄酮中，染料木黄酮是一种潜在的化合物，已发现其通过作用于雄激素受体进一步抑制酪氨酸激酶，从而有效治疗癌症。本文对大豆异黄酮多样生物活性的各个方面及其潜在临床意义与作用机制进行了综述和讨论，尤其涉及在糖尿病、心血管疾病、癌症、骨质疏松症、神经保护方面的治疗与预防，以及大豆异黄酮未来的研究领域。
